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Uncommon Diterpenoids with Diverse Frameworks from the South China Sea Sponge and Their Anti-inflammatory Activities.
J Org Chem
January 2025
School of Medicine, Shanghai University, 99 Shangda Road, BaoShan District, Shanghai 200444, China.
Uncommon diterpenoids with diverse frameworks, including one unexpected iodinated oxa-6/6/6/6-tetracyclic diterpene () and its monobrominated 6/6/6-tricyclic analogue () and one novel isodolastane-type diterpene featuring an unusual aromatic 5/7/6-tricyclic ring system () as well as a related known dolastane-type diterpenoid (), were isolated from the South China Sea sponge . Their structures, including absolute configurations, were established by extensive spectroscopic data analysis, X-ray diffraction analysis, and quantum mechanical-nuclear magnetic resonance and time-dependent density functional theory/electronic circular dichroism calculations. A plausible biosynthetic pathway of new compounds - was proposed.
View Article and Find Full Text PDFBioactive Steroids with Structural Diversity from the South China Sea Soft Coral sp. and Sponge sp.
Mar Drugs
January 2025
Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China.
A chemical investigation of the soft coral sp. and the sponge sp. from the South China Sea led to the isolation of five steroids, including two new compounds ( and ) and one known natural product ().
View Article and Find Full Text PDFFive New Indole Alkaloid Derivatives from Deep-Sea Fungus AF1.
Mar Drugs
December 2024
School of Pharmaceutical Sciences, GBRCE for Functional Molecular Engineering, Sun Yat-sen University, Guangzhou 510006, China.
One new gliotoxin derivative fumianthrogliotoxin (), one new indoquizoline alkaloid 3-(methyl propionate) indoquizoline (), and three novel indole alkaloids, anthroxyindole (), (±)-asperfumiindole A (), and (±)-asperfumiindole B (), together with 16 known compounds (-), were isolated from the culture of deep-sea derived fungus AF1. Their chemical structures and absolute configurations were determined through the analysis of NMR data in combination with electronic circular dichroism (ECD) calculations and other spectroscopic analyses. Compounds - and - were evaluated for anti-pulmonary fibrosis activity.
View Article and Find Full Text PDFSynergistic Antibacterial Action of Norfloxacin-Encapsulated G4 Hydrogels: The Role of Boronic Acid and Cyclodextrin.
Gels
January 2025
"Petru Poni" Institute of Macromolecular Chemistry, Romanian Academy, Centre of Advanced Research in Bionanoconjugates and Biopolymers, Grigore Ghica Voda Alley 41 A, 700487 Iasi, Romania.
In this present study, we developed and characterized a series of supramolecular G4 hydrogels by integrating -cyclodextrin (-CD) and boronic acid linkers into a supramolecular matrix to enhance antibacterial activity against (). We systematically investigated how varying the number of free boronic acid moieties (ranging from two to six), along with guanosine and β-CD content, influences both the structural integrity and antimicrobial efficacy of these materials. Comprehensive characterization using FTIR, circular dichroism, X-ray diffraction, SEM, AFM, and rheological measurements confirmed successful synthesis and revealed that higher boronic acid content correlated with a stronger, more organized network.
View Article and Find Full Text PDFMemantine and Amantadine KLVFF peptide conjugates: Synthesis, structure determination, amyloid-β interaction and effects on recognition memory in mice.
Eur J Pharmacol
January 2025
Department of Drug and Health Sciences, Pharmacology and Toxicology Section, University of Catania, Italy; Oasi Research Institute-IRCCS, 94018 Troina, Italy. Electronic address:
Background: Adamantane derivatives, such as memantine (Mem) and amantadine (Ada), have distinct mechanisms and therapeutic applications. Ada is primarily utilized as an antiviral and anti-Parkinson drug without significant pro-cognitive effects, Mem is effective in various clinical conditions characterized by cognitive deficits, including Alzheimer's disease. Recent evidence highlights a neuroprotective role for Aβ monomers, suggesting that preventing their aggregation into toxic oligomers could be a promising therapeutic strategy.
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