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Recent Development of Nanoparticle Platforms for Organophosphate Nerve Agent Detoxification.
Langmuir
January 2025
Aiiso Yufeng Li Family Department of Chemical and Nano Engineering, Shu and K. C. Chien and Peter Farrell Collaboratory, University of California San Diego, La Jolla, California 92093, United States.
Poisoning by organophosphate (OP) nerve agents remains a pressing global threat due to their extensive use in chemical warfare agents and pesticides, potentially causing high morbidity and mortality worldwide. This urgent need for effective countermeasures has driven considerable interest in innovative detoxification approaches. Among these, nanoparticle technology stands out for its multifunctional potential and wide-ranging applications.
View Article and Find Full Text PDFA review on oxidative stress in organophosphate-induced neurotoxicity.
Int J Biochem Cell Biol
January 2025
Department of Pharmacology and Therapeutics, Faculty of Pharmacy, Kuwait University, Safat 13110, Kuwait. Electronic address:
Acetylcholinesterase inhibition, the principal mechanism of acute organophosphorus compound toxicity, cannot explain neuropsychiatric symptoms occurring after exposure to low organophosphate concentrations causing no cholinergic symptoms. Organophosphate-triggered oxidative stress has increasingly come into focus, occurring when the action of reactive oxygen species, generated from free radicals, is not compensated by antioxidant free radical scavengers. Being nucleophilic, organophosphates can easily accept an electron, thereby generating free radicals.
View Article and Find Full Text PDFEffects of pesticide dichlorvos on liver injury in rats and related toxicity mechanisms.
Ecotoxicol Environ Saf
January 2025
West China Center of Excellence for Pancreatitis, Institute of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China; Regenerative Medicine Research Center, Sichuan University West China Hospital, Chengdu, Sichuan 610041, China. Electronic address:
Dichlorvos (DDVP) is an organophosphorus pesticide commonly utilized in agricultural production. Recent epidemiological studies suggest that exposure to DDVP correlates with an increased incidence of liver disease. However, data regarding the hepatotoxicity of DDVP remain limited.
View Article and Find Full Text PDFA simple acetylcholinesterase inhibition assay for the quantification of the nerve agent VX: Application in a Franz cell model with rat skin and various decontaminants.
Toxicol Lett
January 2025
Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, Munich 80937, Germany; Walther-Straub-Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Goethestrasse 33, Munich 80336, Germany. Electronic address:
The medical community continues to regard organophosphate nerve agent poisoning as a significant concern. Due to the lack of therapeutic options for the nicotinic signs and symptoms for certain agents (e.g.
View Article and Find Full Text PDFAnalysis of Pz-1, a promising therapeutic for organophosphorus poisoning from rodent plasma by liquid chromatography-tandem mass spectrometry.
J Pharm Biomed Anal
March 2025
Department of Chemistry, Biochemistry and Physics, South Dakota State University, Box 2202, Brookings, SD 57007, USA. Electronic address:
Organophosphorus (OP) pesticides (e.g., parathion) and nerve agents (e.
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