Plasma concentrations of immunoreactive corticotrophin (ACTH) have been determined in 14 patients with untreated Addison's disease and in 42 patients with secondary adrenocortical insufficiency. Basal morning plasma ACTH levels were markedly raised in those with Addison's disease but were either in the normal range or undetectable in the group with secondary adrenocortical insufficiency. In the group with Addison's disease circulating ACTH values showed a definite nyctohemeral rhythm, a pronounced rise in response to insulin-induced hypoglycaemia, and an immediate fall following the intravenous injection of corticosteroids, with a half-life of between 13.5 and 44.2 minutes. When assays were performed with antisera directed against the portion of the ACTH molecule responsible for corticosteroidogenesis (the N-terminal portion) the apparent ACTH concentrations were lower than with antisera directed against the non-steroidogenic (C-terminal) portion of the molecule. This emphasizes that different antisera may give different apparent hormone concentrations, and that the ranges of values obtained in normal and abnormal states must be established for each antiserum.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1795012 | PMC |
| http://dx.doi.org/10.1136/bmj.1.5745.374 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Editorial: Rare forms of pediatric adrenal disorders: beyond congenital adrenal hyperplasia due to 21-hydroxylase deficiency.
Front Endocrinol (Lausanne)
December 2024
Centre for Endocrinology, William Harvey Research Institute, Barts & the London School of Medicine & Dentistry, Queen Mary, University of London, London, United Kingdom.
Antenatal Diagnosis and Treatment in Congenital Adrenal Hyperplasia Due to 21-hydroxylase Deficiency and Congenital Adrenal Hyperplasia Screening in Newborns.
J Clin Res Pediatr Endocrinol
January 2025
Marmara University Faculty of Medicine, Department of Pediatric Endocrinology, İstanbul, Turkey
Signs of virilization, such as clitoromegaly, labio-scrotal fusion, and urogenital sinus may be observed in females with 21-hydroxylase deficiency (21-OHD) and other rare virilizing forms of congenital adrenal hyperplasia (CAH). This makes sex determination difficult, and multiple reconstructive surgeries in the postnatal period may be required. As 21-OHD is an autosomal recessive disease, the chance of any child being affected is one in four and so only one in eight will be an affected female.
View Article and Find Full Text PDFLong-survival of a patient with esophageal cancer benefited from comprehensive treatment and MDT: a case report.
J Thorac Dis
November 2024
Department of Oncology, Zhongshan Hospital, Fudan University, Shanghai, China.
Background: Immune checkpoint inhibitors (ICIs) are emerging as important drugs for patients with locally advanced esophageal cancer (EC). Yet, immune-related adverse events (irAEs) may be a major obstacle for these population. Multidisciplinary team (MDT) is an efficient way to deal with such conditions.
View Article and Find Full Text PDFThe Enigma That Is ROHHAD Syndrome: Challenges and Future Strategies.
Brain Sci
October 2024
Bristol Royal Hospital for Children, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol BS2 8BJ, UK.
Rapid-onset obesity with hypoventilation, hypothalamic dysfunction, and autonomic dysregulation (ROHHAD) is a rare syndrome presenting in early childhood associated with a high risk of mortality between 50 and 60%. It is characterised by rapid, early onset of obesity between 1.5-7 years, along with central hypoventilation and hypothalamic dysfunction, such as central hypothyroidism, hyperprolactinemia, disorders of sodium and water balance, growth hormone deficiency, adrenocortical insufficiency, or disorders of puberty and features of autonomic dysregulation.
View Article and Find Full Text PDFAdrenocortical insufficiency after bilateral adrenal hemorrhage due to anticoagulation and chronic immunothrombocytopenia.
Endocrinol Diabetes Metab Case Rep
October 2024
Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich, Zurich, Switzerland.
Article Synopsis
- - Adrenocortical insufficiency is a serious condition caused by a lack of glucocorticoids and/or mineralocorticoids from the adrenal cortex, leading to life-threatening adrenal crises, requiring immediate hydrocortisone treatment.
- - Symptoms like low blood pressure, weight loss, and fatigue are often vague, causing delays in diagnosis; the case study involves a 43-year-old woman who experienced adrenal insufficiency due to bleeding in her adrenal glands while also having immune thrombocytopenia (ITP).
- - Proper diagnosis is crucial, especially in patients with bleeding risk factors, and treatment typically starts with high doses of hydrocortisone and possibly fludrocortisone, which can later be adjusted as
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!