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Chemical composition and insecticidal efficacy of two animals' horn and hoof crude extracts against lesser grains borer, (F.) [Coleoptera: Bostrichidae].
Heliyon
January 2025
Department of Animal Production and Health, School of Agriculture and Agricultural Technology, Federal University of Technology,P. M. B. 704, Akure, Ondo State, Nigeria.
This research evaluated the profiling of bioactive compounds and insecticidal activities of the crude extracts of horns and hoofs of cow and goat against on wheat grains. Different concentrations (0.1, 0.
View Article and Find Full Text PDFMicroRNAs in pancreatic cancer drug resistance: mechanisms and therapeutic potential.
Front Cell Dev Biol
January 2025
Department of Surgery, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China.
Pancreatic cancer (PC) remains one of the most lethal malignancies, primarily due to its intrinsic resistance to conventional therapies. MicroRNAs (miRNAs), key regulators of gene expression, have been identified as crucial modulators of drug resistance mechanisms in this cancer type. This review synthesizes recent advancements in our understanding of how miRNAs influence treatment efficacy in PC.
View Article and Find Full Text PDFAlien toxic toads suppress individual growth and phenotypic development of native predatory salamanders.
Oecologia
January 2025
Tomakomai Experimental Forest, Field Science Center for Northern Biosphere, Hokkaido University, Takaoka, Tomakomai, Hokkaido, 053-0035, Japan.
Alien species can influence populations of native species through individual-level effects such as predation, competition, and poisoning. For alien species that possess strong defensive chemicals, poisoning is one of the most powerful mechanisms of individual-level effects on native biota. Although toxic alien species could potentially negatively affect survival (lethal effects) or life history traits (sub-lethal effects) of native predators via poisoning, previous studies have mainly focused on acute lethal effects.
View Article and Find Full Text PDFEx vivo electrophysiological evaluation of peripheral nerve functioning following exposition of adult mice to the organophosphorus pesticide chlormephos.
Environ Toxicol Pharmacol
January 2025
Université Paris-Saclay, CEA, Institut des sciences du vivant Frédéric Joliot, Département Médicaments et Technologies pour la Santé (DMTS), Service d'Ingénierie Moléculaire pour la Santé (SIMoS), EMR CNRS/CEA 9004, 91191 Gif-sur-Yvette, France. Electronic address:
The organophosphorus pesticide chlormephos was tested for its potential peripheral neurotoxicity by analyzing the diphasic compound action potential (CAP) of sciatic nerves isolated from adult mice chronically exposed to a sub-lethal dose of this pesticide, compared with control age-matched animals being only exposed to the vehicle. No significant modification was detected between chlormephos-exposed and control groups in their nerve responsiveness to stimulus. Furthermore, similar values of CAP kinetic variables were obtained from the two mouse groups.
View Article and Find Full Text PDFDesign, Synthesis, Biocompatibility, molecular docking and molecular dynamics studies of novel Benzo[b]thiophene-2-carbaldehyde derivatives targeting human IgM Fc Domains.
Bioorg Chem
January 2025
Department of Chemistry, St Berchmans College (Autonomous), Changanassery, Kerala 686101, India; Centre for Theoretical and Computational Chemistry, St Berchmans College (Autonomous), Changanassery, Kerala 686101, India. Electronic address:
In this study, three novel derivatives of benzo[b]thiophene-2-carbaldehyde (BTAP1, BTAP2, and BTAP3) were successfully synthesized and comprehensively characterized using spectroscopic techniques including FTIR, UV-VIS, HNMR, and CNMR. Thermal analysis through TGA and DTA demonstrated remarkable thermal stability with a maximum threshold at 270 °C. Spectroscopic investigations revealed π → π* transitions in all compounds, attributed to the conjugated system comprising benzothiophene rings connected to bromophenyl/ aminophenyl/phenol rings via α, β-unsaturated ketone bridges.
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