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Coconut oil reduces steroidogenic enzymes and imbalances estrogen receptors in the adrenal cortex of Mongolian gerbils.
Food Chem Toxicol
January 2025
Department of Biological Sciences, Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University (UNESP), São Paulo, Brazil. Electronic address:
This study aims to verify the effects of prolonged ingestion of coconut oil on the adrenal glands of Mongolian gerbils. Mongolian gerbils were used as an experimental model due to the morphological similarity of the adrenal glands to those of primates. Male Mongolian gerbils, 3 months of age, were divided into three experimental groups (n = 12): an intact control group, which received no treatment, a gavage control group, which received 0.
View Article and Find Full Text PDFSARS-CoV-2-induced cytokine storm drives prolonged testicular injury and functional impairment in mice that are mitigated by dexamethasone.
PLoS Pathog
January 2025
Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, United States of America.
Compromised male reproductive health, including reduced testosterone and sperm count, is one of the long COVID symptoms in individuals recovering from mild-severe disease. COVID-19 patients display testicular injury in the acute stage and altered serum fertility markers in the recovery phase, however, long-term implications on the testis remain unknown. This study characterized the consequences of SARS-CoV-2 on testis function.
View Article and Find Full Text PDFProfiling steroid hormone landscape of bladder cancer reveals depletion of intratumoural androgens to castration levels: a cross-sectional study.
EBioMedicine
October 2024
Institute of Biomedicine and FICAN West Cancer Centre, University of Turku, Turku, Finland; Department of Pathology, Turku University Hospital, Turku, Finland. Electronic address:
Background: Bladder cancer is a highly over-represented disease in males. The involvement of sex steroids in bladder carcinogenesis and the utilisation of steroid hormone action as a therapeutic target have been frequently proposed. However, the intratumoural steroid milieu remains unclear.
View Article and Find Full Text PDFEstablishment of Star-edited Y1 cells as a novel in vitro functional assay for STAR.
J Mol Endocrinol
November 2024
Department of Pediatrics, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
Article Synopsis
- - The study focuses on genetic variants of the STAR protein that lead to lipoid congenital adrenal hyperplasia, a condition marked by disrupted steroid production in adrenal glands and gonads.
- - Researchers created genetically modified Y1 mouse tumor cells, which showed a slight ability to produce pregnenolone, and displayed changes similar to those found in patients with the condition when stimulated for two weeks.
- - The modified cells can assess the functionality of both mouse and human STAR proteins, providing a new way to study genetic variants linked to steroidogenesis issues.
Bioengineered 3D ovarian model for long-term multiple development of preantral follicle: bridging the gap for poly(ε-caprolactone) (PCL)-based scaffold reproductive applications.
Reprod Biol Endocrinol
August 2024
Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100, Teramo, Italy.
Background: Assisted Reproductive Technologies (ARTs) have been validated in human and animal to solve reproductive problems such as infertility, aging, genetic selection/amplification and diseases. The persistent gap in ART biomedical applications lies in recapitulating the early stage of ovarian folliculogenesis, thus providing protocols to drive the large reserve of immature follicles towards the gonadotropin-dependent phase. Tissue engineering is becoming a concrete solution to potentially recapitulate ovarian structure, mostly relying on the use of autologous early follicles on natural or synthetic scaffolds.
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