A single-approximately LD50-dosis of the 3-AP given to white rats following the unilateral ligature of the carotid artery in almost 70 percent of the animals caused hydropic-vacuolic degeneration and cell necrosis in the nucleus ruber. Similar changes were quite infrequent in the mesenphalic nuclei. The regressiv changes can be prevented by nicotinamid. When smaller doses are given they do not occur at all. Electronmicroscopic findings help to explain some aspects of the pathogenesis of these rather selective changes.
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