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Alzheimer's disease (AD), a leading cause of dementia, is associated with significant respiratory dysfunctions. Our study explores the role of astrogliosis in the brainstem retrotrapezoid nucleus (RTN), a key breathing regulatory center, and its impact on breathing control and AD pathology in mice. Using Tg-2576 AD and wild-type mice, we investigated the effect of silencing the transforming growth factor-beta receptor II (TGFβR II) in the RTN.
View Article and Find Full Text PDFTransforming Feather Meal Into a High-Performance Feed for Broilers.
Vet Med Sci
January 2025
Department of Industrial Management, Faculty of Humanities, University of Tehran, Kish International Campus, Tehran, Iran.
Background: The poultry industry faces challenges with the high cost and environmental impact of Soybean meal. Feather meal, a byproduct with low digestibility due to its keratin content, is a potential alternative. Recent biotechnological advances, including enzymatic and bacterial hydrolysis, have enhanced its digestibility and nutritional value.
View Article and Find Full Text PDFEV-idence uncovered: kidney-on-chip study links circulating EVs of cardiorenal syndrome to renal pathology.
Extracell Vesicles Circ Nucl Acids
October 2024
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA.
The intertwined nature of cardiac and renal failure, where dysfunction in one organ predicts a poor outcome in the other, has long driven the interest in uncovering the exact molecular links between the two. Elucidating the mechanisms driving Cardiorenal Syndrome (CRS) will enable the development of targeted therapies that disrupt this detrimental cycle, potentially improving outcomes for patients. A recent study by Chatterjee .
View Article and Find Full Text PDFHot shape transformation: the role of PSar dehydration in stomatocyte morphogenesis.
Beilstein J Org Chem
January 2025
Institute of Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands.
Polysarcosine emerges as a promising alternative to polyethylene glycol (PEG) in biomedical applications, boasting advantages in biocompatibility and degradability. While the self-assembly behavior of block copolymers containing polysarcosine-containing polymers has been reported, their potential for shape transformation remains largely untapped, limiting their versatility across various applications. In this study, we present a comprehensive methodology for synthesizing, self-assembling, and transforming polysarcosine-poly(benzyl glutamate) block copolymers, resulting in the formation of bowl-shaped vesicles, disks, and stomatocytes.
View Article and Find Full Text PDFTRIF-TAK1 signaling suppresses caspase-8/3-mediated GSDMD/E activation and pyroptosis in influenza A virus-infected airway epithelial cells.
iScience
January 2025
College of Veterinary Medicine, Institute of Comparative Medicine, Yangzhou University, Yangzhou 225009, Jiangsu Province, P.R. China.
Pyroptosis plays an important role in attracting innate immune cells to eliminate infected niches. Our study focuses on how influenza A virus (IAV) infection triggers pyroptosis in respiratory epithelial cells. Here, we report that IAV infection induces pyroptosis in a human and murine airway epithelial cell line.
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