The clinical records and microscopic sections from 32 patients were reviewed in an attempt to correlate histopathologic features with clinical behavior. Three general clinical groups were identified on the basis of recurrence rates and extent of papillomatosis. In those lesions with the highest frequency of recurrences, epithelial atypia tended to be most pronounced. Although some of the lesions were quite disturbing, there was no evidence of invasive carcinoma. It remains unknown to date whether these cytologic abnormalities represent a neoplastic alteration or possibly atypia on the basis of rapid, but benign, cellular turnover. Further studies at our center and other institutions are necessary to test the proposed classification which, if validated, would provide a means of predicting the course of the disease and efficacy of the chosen management in these difficult cases.
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Article Synopsis
- The study aimed to examine whether specific clinical, radiological, or histological features can distinguish breast hamartomas associated with atypia/malignancy from benign hamartomas without such complications.
- A review of 450 hamartomas from 2010 to 2023 revealed that only 4.2% were linked to atypia or malignancy.
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