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Cannabis consumption and risk of asthma: a systematic review and meta-analysis.
BMC Pulm Med
January 2025
Global Health and Infectious Diseases Control Institute, Nasarawa State University, Keffi, Nigeria.
Background: Cannabis is the third most widely used psychoactive substance globally, and its consumption has been increasing, particularly with the growing trend of legalization for medicinal and recreational use. Recent studies have raised concerns about the potential impact of cannabis on respiratory health, specifically the risk of asthma, a significant public health concern. This systematic review aimed to consolidate research on the association between cannabis use and the risk of asthma.
View Article and Find Full Text PDFRemimazolam for procedural sedation in gastrointestinal endoscopy: real-life, single center observational study.
BMC Gastroenterol
January 2025
Gastroenterology and Digestive Endoscopy Unit, Azienda Ospedaliero Universitaria Modena, Modena, Italy.
Background And Aim: Remimazolam has proved to be a very promising sedative drug in randomized clinical trials for usage in a wide spectrum of patients, including critically ill ones. The purpose of our study was to verify efficacy and safety of remimazolam for procedural sedation during diagnostic and first level operative endoscopy in a real-world setting.
Methods: This single centre prospective study evaluated sedation regimen with remimazolam for EGDS and fentanyl and remimazolam for colonoscopy in consecutive ASA 1-3 patients.
Niche-derived Semaphorin 4A safeguards functional identity of myeloid-biased hematopoietic stem cells.
Nat Aging
January 2025
Translational Science and Therapeutics Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Somatic stem cell pools comprise diverse, highly specialized subsets whose individual contribution is critical for the overall regenerative function. In the bone marrow, myeloid-biased hematopoietic stem cells (myHSCs) are indispensable for replenishment of myeloid cells and platelets during inflammatory response but, at the same time, become irreversibly damaged during inflammation and aging. Here we identify an extrinsic factor, semaphorin 4A (Sema4A), which non-cell-autonomously confers myHSC resilience to inflammatory stress.
View Article and Find Full Text PDFA clinical narrative corpus on nut allergy: annotation schema, guidelines and use case.
Sci Data
January 2025
Computer Science and Engineering Department, Universidad Carlos III de Madrid, Av. Universidad, 30, Leganés, 28911, Madrid, Spain.
This article describes a dataset on nut allergy extracted from Spanish clinical records provided by the Hospital Universitario Fundación de Alcorcón (HUFA) in Madrid, Spain, in collaboration with its Allergology Unit and Information Systems and Technologies Department. There are few publicly available clinical texts in Spanish and having more is essential as a valuable resource to train and test information extraction systems. In total, 828 clinical notes in Spanish were employed and several experts participated in the annotation process by categorizing the annotated entities into medical semantic groups related to allergies.
View Article and Find Full Text PDFThe Efficacy of Superior Laryngeal Nerve Block for Chronic Cough: A Scoping Review.
J Voice
January 2025
Department of Otolaryngology-Head and Neck Surgery, Wake Forest University School of Medicine, Winston-Salem, NC.
Objective: Chronic cough poses diagnostic and treatment challenges due to its often multifactorial nature. Chronic cough associated with laryngeal hypersensitivity is linked to sensory neuropathy of the superior laryngeal nerve and can be complex to manage. Superior laryngeal nerve (SLN) blocks are increasingly being utilized by laryngologists to treat refractory chronic cough with the intent of reducing inflammation and nerve hypersensitivity.
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