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Advances in our understanding of the estrous cycle and applications for improving targeted reproductive management in livestock.
Domest Anim Endocrinol
January 2025
USDA, ARS, U.S. Meat Animal Research Center, Clay Center, NE, USA.
The scientific discipline of endocrinology has been invaluable to our understanding of the estrous cycle. In the second half of the twentieth century the development of immunoassay technologies provided a rapid and sensitive method to quantify circulating concentrations of reproductive hormones and relate them to stage of the estrous cycle and physiological status of the animal. Ovarian ultrasonography provided the ability to track the growth and regression of ovarian structures within the same animal across the estrous cycle in real time and, in combination with hormonal profiling, accurately identify mechanisms regulating the estrous cycle and early pregnancy.
View Article and Find Full Text PDFAdvancing Immunoassay Precision: A Novel Preanalytical Method for Enhancing Thyroglobulin Measurement in the Presence of Tg Antibodies.
Int J Mol Sci
December 2024
Institute for the Application of Nuclear Energy INEP, University of Belgrade, Banatska 31b, 11080 Belgrade, Serbia.
Thyroglobulin (Tg) is a reliable marker for detecting recurrence in differentiated thyroid cancer (DTC) patients, but frequently occurring Tg antibodies (TgAbs) can hinder accurate measurement. We aimed to develop a preanalytical protocol for precise Tg detection in TgAb presence using the immunoradiometric assay (IRMA) platform. This study involved forty-five patients who underwent IRMA Tg and radioimmunoassay (RIA) TgAb measurements, including two patients monitored for recurrence and one with confirmed recurrence.
View Article and Find Full Text PDFEvaluation of a Chemiluminescent Enzyme Immunoassay for the Detection of Prostaglandin E-Major Urinary Metabolite (PGE-MUM).
J Clin Lab Anal
October 2024
Research and Development Division, FUJIREBIO Inc., Tokyo, Japan.
Background: We developed a fully automated quantitative immunoassay for the detection of prostaglandin E-major urinary metabolite (PGE-MUM). In this study, we evaluated the analytical performance of this assay.
Methods: Sensitivity, within-run reproducibility, correlation with radioimmunoassay (RIA), cross-reactivity, dilution linearity, spike recovery performance, analyte stability, and effects of coexisting substances were evaluated.
One-step detection of procollagen type III N-terminal peptide as a fibrosis biomarker using fluorescent immunosensor (quenchbody).
Anal Chim Acta
August 2024
Doping Control Center, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea. Electronic address:
Background: Procollagen type III N-terminal peptide (P-III-NP) is a fibrosis biomarker associated with liver and cardiac fibrosis. Despite the value of P-III-NP as a biomarker, its analysis currently relies on enzyme-linked immunosorbent assays (ELISA) and radioimmunoassays (RIA), which require more than 3 h. To facilitate early diagnosis and treatment through rapid biomarker testing, we developed a one-step immunoassay for P-III-NP using a quenchbody, which is a fluorescence-labeled immunosensor for immediate signal generation.
View Article and Find Full Text PDFAssessment of stress levels and reproductive condition in giant pandas: insights from hair, faecal and saliva samples.
Conserv Physiol
July 2024
Key Laboratory for Biodiversity and Ecological Engineering of Ministry of Education, Department of Ecology, College of Life Sciences, Beijing Normal University, No.19, Xinjiekouwai Street, Haidian District, Beijing 100875, China.
Article Synopsis
- Conservation efforts have helped the giant panda rebound from near extinction, but they still face threats from human activities, and low breeding success in captivity persists.
- This study focused on measuring hormone levels (testosterone, estradiol, progesterone, and cortisol) in panda hair and comparing them to faecal samples to evaluate stress and reproductive health.
- Results indicated that hormone levels varied monthly and demonstrated a significant correlation between hair and faecal cortisol, providing a potential method for monitoring panda welfare and assessing conservation success.
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