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GnIH secreted by green light exposure, regulates bone mass through the activation of Gpr147.
Bone Res
January 2025
Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Tongji University School of Medicine, Shanghai, PR China.
Reproductive hormones associated with the hypothalamic-pituitary-gonadal (HPG) axis are closely linked to bone homeostasis. In this study, we demonstrate that Gonadotropin inhibitory hormone (GnIH, one of the key reproductive hormones upstream of the HPG axis) plays an indispensable role in regulating bone homeostasis and maintaining bone mass. We find that deficiency of GnIH or its receptor Gpr147 leads to a significant reduction in bone mineral density (BMD) in mice primarily by enhancement of osteoclast activation in vivo and in vitro.
View Article and Find Full Text PDFKisspeptin participates in the positive reward state induced by paced mating and modulates sexual receptivity and paced mating behavior in female rats.
Horm Behav
January 2025
Escuela Nacional de Estudios Superiores Unidad Juriquilla, Universidad Nacional Autonóma de México, Campus UNAM-Juriquilla, 76230 Querétaro, Mexico; Instituto de Neurobiología, Universidad Nacional Autonóma de México, Campus UNAM-Juriquilla, 76230 Querétaro, Mexico.
Kisspeptin (Kp), a potent regulator of the hypothalamic-pituitary-gonad axis, was recently shown to be involved in partner preference and sexual receptivity in females. Interestingly, Kp and its receptor (Kiss1r) are expressed in brain regions involved in the reward and motivation of reinforcing behaviors. Therefore, in the present study, we designed 3 experiments to determine the participation of Kp in female sexual behavior and the positive affective (PA) reward state induced by paced mating (PM).
View Article and Find Full Text PDFEstrogens impair hypophagia and hypothalamic cell activation induced by vasoactive intestinal peptide, but not by pituitary adenylate cyclase-activating polypeptide.
Peptides
January 2025
Programa Multicêntrico de Pós-Graduação em Ciências Fisiológicas, Universidade Estadual de Londrina, Londrina, PR, Brazil; Programa de Pós-Graduação em Ciências Fisiológicas, Universidade Estadual de Londrina, Londrina, PR, Brazil; Laboratório de Fisiologia Neuroendócrina e Metabolismo, Departamento de Ciências Fisiológicas, Universidade Estadual de Londrina, Londrina, PR, Brazil. Electronic address:
Article Synopsis
- The study investigated how estradiol affects food intake and receptor expression in postmenopausal rats, particularly looking at the neuropeptides VIP and PACAP in specific hypothalamic areas.
- Results showed that estradiol reduced the expression of the VPAC2 receptor and disrupted the hypophagic (appetite-reducing) effects of VIP, while PACAP continued to suppress food intake.
- Additionally, estradiol altered plasma glucose and free fatty acid levels in these rats, suggesting different mechanisms in how VIP and PACAP influence energy homeostasis in the context of estrogen loss.
Estradiol affects the expression of essential molecular factors involved in luteinizing hormone secretion in the plains vizcacha.
Gen Comp Endocrinol
January 2025
Centro de Estudios Biomédicos Básicos, Aplicados y Desarrollo (CEBBAD), Universidad Maimónides, Hidalgo 775 6to piso, C1405BCK Ciudad Autónoma de Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Godoy Cruz 2290, C1425FQB Ciudad Autónoma de Buenos Aires, Argentina. Electronic address:
The plains vizcacha is a rodent that shows reactivation of the hypothalamic-pituitary-ovary (HPO) axis activity at mid-gestation. This process is enabled by the secretion of hypothalamic gonadotropin-releasing hormone (GnRH) at mid-gestation, followed by follicle-stimulating hormone (FSH) and luteinizing hormone (LH) secretion. However, a decrease in the pituitary GnRH receptor (GnRHR) expression is concomitantly determined.
View Article and Find Full Text PDFAmeliorative effect of α-tocopherol and tocotrienol-rich palm oil extract on menopause-associated mood disorder in ovariectomized mice.
Biochem Biophys Res Commun
November 2024
Faculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur, 56000, Malaysia; Office of Postgraduate Studies, UCSI University, Kuala Lumpur, 56000, Malaysia; UCSI Wellbeing Research Centre, UCSI University, Kuala Lumpur, 56000, Malaysia. Electronic address:
Article Synopsis
- * A study evaluated the effects of vitamin E compounds—α-tocopherol and tocotrienol-rich palm oil extract—on anxiety and depressive behaviors in mice with estrogen deficiency, finding that these compounds had positive effects on mood-related behaviors.
- * The results indicated that both supplements reduced stress hormone levels and improved symptoms, suggesting they could be a promising new treatment option for menopause-related mood disorders, potentially influencing the hypothalamic-pituitary-adrenal (HPA) axis.
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