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This study aimed to develop and validate machine learning (ML) models to predict the occurrence of delayed hyponatremia after transsphenoidal surgery for pituitary adenoma. We retrospectively collected clinical data on patients with pituitary adenomas treated with transsphenoidal surgery between January 2010 and December 2020. From January 2021 to December 2022, patients with pituitary adenomas were prospectively enrolled.
View Article and Find Full Text PDFUrinary oxytocin secretion after pituitary surgery, early arginine vasopressin deficiency and syndrome of inappropriate antidiuresis.
Endocrine
December 2024
Department of Neurosurgery, Hôpitaux Universitaires de Genève (HUG), Geneva, Switzerland.
Purpose: Transient arginine vasopressin deficiency (AVP-D), previously called diabetes insipidus, is a well-known complication of transsphenoidal pituitary surgery (TPS) with no definite predictive biomarker to date making it difficult to anticipate. While oxytocin (OXT) was previously suggested as a possible biomarker to predict syndrome of inappropriate diuresis (SIAD)-related hyponatraemia after TPS, its secretion in patients presenting with AVP-D remains poorly understood. We therefore hypothesized that OXT might present a different secretion in the case of AVP-D which would support its potential as an early biomarker of AVP-D.
View Article and Find Full Text PDFEndocrine effects of MEK and BRAF inhibitor therapy in paediatric patients: a tertiary centre experience.
J Neurooncol
December 2024
UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Article Synopsis
- The study investigates the side effects of BRAF and MEK inhibitors used for treating low-grade gliomas in children, focusing on endocrine dysfunction, particularly glucose dysregulation and hyponatraemia.
- The analysis reviewed data from 55 pediatric patients treated with these inhibitors from January 2019 to May 2022, finding that some experienced episodes of low sodium levels, especially those with central diabetes insipidus.
- Clinicians are advised to closely monitor sodium and glucose levels in patients undergoing treatment to manage the risks associated with these medications effectively.
Unraveling the Mystery of Rathke's Cleft Cyst Presenting with Hyponatremia: A Case Report with a Comprehensive Review of Literature.
Asian J Neurosurg
December 2024
Department of Neurosurgery, Lenox Hill Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, New York, United States.
Article Synopsis
- Rathke's cleft cyst (RCC) is a benign cyst that usually goes unnoticed but can be associated with rare cases of hyponatremia due to inappropriate antidiuretic hormone (SIADH) secretion.
- The case study discusses a 56-year-old woman who experienced symptoms like blurry vision and headaches, ultimately diagnosed with euvolemic hyponatremia linked to RCC, which was treated effectively via endoscopic surgery.
- The article emphasizes the need for careful evaluation and a multidisciplinary approach in managing such rare instances, while calling for more research to enhance understanding and treatment strategies for RCC related to SIADH.
Cavitating Osmotic Demyelination Syndrome Following Correction of Chronic Hyponatremia in Sheehan's Syndrome: A Novel Case Report.
Neurohospitalist
September 2024
Department of Neurology, University Hospital "12 de Octubre", Madrid, Spain.
Article Synopsis
- Rapid correction of chronic hyponatremia can lead to osmotic demyelination syndrome (ODS), especially in patients with underlying conditions like Sheehan’s syndrome, a rare pituitary disorder following severe postpartum hemorrhage.
- A case report details a 40-year-old woman who experienced neurological decline due to the correction of her long-standing hyponatremia, which had been mismanaged for years, leading to extrapontine and then central pontine myelinolysis.
- The case emphasizes that even gradual correction of low sodium levels poses risks and highlights the need for careful management in patients with chronic hyponatremia and related conditions.
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