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Leukocyte scintigraphy has high specificity but low sensitivity in diagnosing persistent periprosthetic joint infection before reimplantation in two-stage revision.
Arch Orthop Trauma Surg
January 2025
IIa Clinica Ortopedica e Traumatologica, IRCCS Istituto Ortopedico Rizzoli, Via Pupilli 1/10, 40136, Bologna, Italy.
Introduction: Two-stage revision is considered the gold standard treatment in chronic periprosthetic joint infection (PJI) but no specific criteria or examination exist to determine infection eradication before reimplantation. This study aimed to assess the diagnostic performance of leukocyte scintigraphy after the first-stage procedure in two-stage revision for chronic PJI.
Material And Methods: Patients studied with leukocyte scintigraphy after cement spacer insertion for knee PJI from January 2012 to December 2021 were retrospectively included.
Minimally important change on the Columbia Impairment Scale and Strengths and Difficulties Questionnaire in youths seeking mental healthcare.
BMJ Ment Health
January 2025
Cundill Centre for Child and Youth Depression, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Background: Evidence-based mental health requires patient-relevant outcome data, but many indicators lack clinical meaning and fail to consider youth perceptions. The minimally important change (MIC) indicator designates change as meaningful to patients, yet is rarely reported in youth mental health trials.
Objective: This study aimed to establish MIC thresholds for two patient-reported outcome measures (PROMs), the Columbia Impairment Scale (CIS) and the Strengths and Difficulties Questionnaire (SDQ), using different estimation methods.
Contrast-enhanced ultrasound-based AI model for multi-classification of focal liver lesions.
J Hepatol
January 2025
CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, China; School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing, China. Electronic address:
Background & Aims: Accurate multi-classification is the prerequisite for reasonable management of focal liver lesions (FLLs). Ultrasound is the common image examination, but lacks accuracy. Contrast enhanced ultrasound (CEUS) offers better performance, but highly relies on experience.
View Article and Find Full Text PDFWavefront sensing: A breakthrough for objective evaluation of dynamic accommodation in accommodative dysfunctions.
Comput Biol Med
January 2025
Centre of Physics of the Universities of Minho and Porto, University of Minho, 4710-057, Braga, Portugal. Electronic address:
The purpose of this study was to use wavefront sensing as an objective method to detect and assess dynamic accommodation in subjects with accommodative dysfunctions and symptoms related to near-vision tasks. Sixty-three subjects were divided into control (N = 18), symptomatic without any accommodative dysfunction (SWD) (N = 18), infacility of accommodation (INFA) (N = 6), excess of accommodation (EA) (N = 9), and insufficiency of accommodation (INSA) (N = 12) groups. Accommodation was stimulated in different cycles of accommodation and disaccommodation while ocular aberrations were measured.
View Article and Find Full Text PDFPostural instability and gait disturbance are associated with abnormal stereopsis in Parkinson's disease.
PLoS One
January 2025
Department of Neurology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
Background: Visual dysfunction, including abnormal stereopsis, is a significant non-motor symptom in Parkinson's disease (PD) that can reduce quality of life and appears early in the disease. Abnormal stereopsis is associated with worsening of bradykinesia and freezing of gait, though the exact pathways linking stereopsis to motor symptoms remain unclear. Furthermore, in PD patients, the pedunculopontine nucleus and laterodorsal tegmental complex play an active role in sensorimotor control, and these areas provide cholinergic projections.
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