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Effectiveness of Acetazolamide in Patients With Heart Failure: A Systematic Review and Meta-Analysis.
Cureus
December 2024
Nephrology, Fatima Memorial Hospital, Karachi, PAK.
This systematic review and meta-analysis evaluated the efficacy and safety of acetazolamide as an adjunctive diuretic therapy in acute heart failure (AHF) patients. A comprehensive literature search was conducted across multiple electronic databases, including PubMed, Embase, Cochrane Library, and Scopus, identifying seven studies (five randomized controlled trials and two observational studies) that met the eligibility criteria. The analysis revealed that acetazolamide significantly enhanced mean natriuresis (mean differences (MD) 52.
View Article and Find Full Text PDFKidney Gastrin/CCKBR Attenuates Type 2 Diabetes Mellitus by Inhibiting SGLT2-Mediated Glucose Reabsorption through Erk/NF-κB Signaling Pathway.
Diabetes Metab J
December 2024
Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Center, Peking Union Medical College (PUMC), and Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Beijing, China.
Background: Both sodium-glucose cotransporters (SGLTs) and Na+/H+ exchangers (NHEs) rely on a favorable Na-electrochemical gradient. Gastrin, through the cholecystokinin B receptor (CCKBR), can induce natriuresis and diuresis by inhibiting renal NHEs activity. The present study aims to unveil the role of renal CCKBR in diabetes through SGLT2-mediated glucose reabsorption.
View Article and Find Full Text PDFObservational study for multiparametric assessment of cardiac congestion in outpatient worsening heart failure (EVOLUTION).
Eur J Heart Fail
December 2024
Université Paris Cité, INSERM UMR-S 942 (MASCOT), Paris, France.
Article Synopsis
- The study aimed to understand the outcomes of patients experiencing worsening heart failure (WHF) while receiving outpatient treatment and to identify factors linked to poor responses to loop diuretics.
- Between September 2022 and March 2023, 44 patients with WHF symptoms were monitored weekly; improvements in symptoms and quality of life were noted, but certain biomarkers indicated a risk for poor diuretic response.
- High levels of cystatin C, NT-proBNP, and troponin T were found to be strong indicators of inadequate response to fluid treatment in these patients, suggesting a need for alternative therapies for those affected.
Urinary oxytocin secretion after pituitary surgery, early arginine vasopressin deficiency and syndrome of inappropriate antidiuresis.
Endocrine
December 2024
Department of Neurosurgery, Hôpitaux Universitaires de Genève (HUG), Geneva, Switzerland.
Purpose: Transient arginine vasopressin deficiency (AVP-D), previously called diabetes insipidus, is a well-known complication of transsphenoidal pituitary surgery (TPS) with no definite predictive biomarker to date making it difficult to anticipate. While oxytocin (OXT) was previously suggested as a possible biomarker to predict syndrome of inappropriate diuresis (SIAD)-related hyponatraemia after TPS, its secretion in patients presenting with AVP-D remains poorly understood. We therefore hypothesized that OXT might present a different secretion in the case of AVP-D which would support its potential as an early biomarker of AVP-D.
View Article and Find Full Text PDFNatriuresis-Guided Diuresis in Patients Admitted to Hospital With Heart Failure: Barking up the Wrong Tree?
J Card Fail
December 2024
Department of Cardiology, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Cottingham, Kingston-Upon-Hull, East Riding of Yorkshire, HU16 5JQ, UK.
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