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Similar Publications
Special Collection: Implementation Research Evidence for Prevention and Treatment of Postpartum Hemorrhage in High-Burden Low- and Middle-Income Countries.
Int J MCH AIDS
September 2024
The Center for Global Health and Health Policy, Global Health and Education Projects, Inc., Riverdale, Maryland, USA.
Article Synopsis
- - Postpartum hemorrhage (PPH) is a serious condition defined as losing 500 mL or more of blood within the first 24 hours after childbirth, and it is responsible for over 20% of global maternal deaths, particularly affecting low- and middle-income countries.
- - Coordinated efforts from the global maternal health community are essential to achieve the Sustainable Development Goal 3 target for maternal health by 2030 amid the ongoing burden of PPH.
- - A Special Collection by the International Journal of Maternal and Child Health and AIDS and the Concept Foundation highlights the effectiveness of heat-stable carbetocin and tranexamic acid in preventing and managing PPH, especially in resource-limited settings.
A Tale of Two Medicines: The Need for Ownership, End-to-End Planning and Execution for Development and Introduction of Maternal Health Medicines.
Int J MCH AIDS
September 2024
Concept Foundation, Avenue de Sécheron, Geneva, Switzerland.
Article Synopsis
- - Postpartum hemorrhage (PPH) is a leading cause of maternal death in low- and middle-income countries (LMICs), and the WHO recommends heat-stable carbetocin and tranexamic acid to prevent and treat it.
- - Implementation of these recommended drugs is hindered by issues like disorganized procurement, poor quality control, and limited access in many LMICs.
- - Despite having safety and efficacy data, access challenges differ between the two drugs, necessitating coordinated actions for better availability of essential maternal health commodities.
Feasibility, Acceptability, and Appropriate Use of Novel and Lesser-Used Medicines for Prevention and Treatment of Postpartum Hemorrhage: Evidence from Implementation Research.
Int J MCH AIDS
September 2024
Concept Foundation, Avenue de Sécheron, Geneva, Switzerland.
Article Synopsis
- * Effective uterotonics, including heat-stable carbetocin (HSC) and tranexamic acid (TXA), can significantly lower PPH-related deaths and complications.
- * Implementation challenges like policy updates and lack of training hinder access to these essential medicines; however, research in nine LMICs shows that HSC and TXA are feasible and acceptable for healthcare providers, supporting their integration into obstetric care.
Postpartum Hemorrhage in Humanitarian Settings: Implementation Insights from Using Heat-Stable Carbetocin and Tranexamic Acid.
Int J MCH AIDS
September 2024
United Nations Population Fund, Humanitarian Response Division, Switzerland.
Article Synopsis
- Maternal mortality due to postpartum hemorrhage (PPH) is a significant issue in low-resource settings, and this study examines healthcare providers' perspectives on the effectiveness and challenges of using heat-stable carbetocin (HSC) and tranexamic acid (TXA) for prevention and treatment of PPH.
- The research involved semi-structured interviews and focus group discussions with 64 healthcare workers in South Sudan and Uganda, focusing on a PPH intervention package that included training, readiness kits, and a community support platform.
- Results indicated providers view HSC favorably for preventing bleeding and recognize TXA as effective but noted limited experience with it; challenges included medication confusion and record-keeping issues, while
Postpartum Hemorrhage in Humanitarian Settings: Heat-Stable Carbetocin and Tranexamic Acid Implementation Study in South Sudan.
Int J MCH AIDS
September 2024
United Nations Population Fund, Humanitarian Response Division, Switzerland.
Article Synopsis
- The study assesses the impact of a capacity-strengthening package on the use of medications for preventing and treating postpartum hemorrhage (PPH) in South Sudan's basic maternity facilities.
- The implementation involved a series of phases introducing therapeutic protocols, including training and resources, resulting in improved use of uterotonics and a notable increase in PPH diagnoses.
- Findings indicate a transition in medication usage patterns, with oxytocin usage decreasing as heat-stable carbetocin and tranexamic acid were introduced, highlighting the need for effective PPH management strategies in crisis-affected areas.
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