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Painful diabetic neuropathy is associated with accelerated epigenetic aging.
Geroscience
January 2025
Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.
About one out of two diabetic patients develop diabetic neuropathy (DN), of these 20% experience neuropathic pain (NP) leading to individual, social, and health-economic burden. Risk factors for NP are largely unknown; however, premature aging was recently associated with several chronic pain disorders. DNA methylation-based biological age (DNAm) is associated with disease risk, morbidity, and mortality in different clinical settings.
View Article and Find Full Text PDFPredictive Value of Flow Cytometry Quantification of BAL Lymphocytes and Neutrophils in ILD.
Cells
December 2024
Immunology Service, Clinical University Hospital Virgen de la Arrixaca (HCUVA), Biomedical Research Institute of Murcia Pascual Parrilla (IMIB), 30120 Murcia, Spain.
Interstitial lung diseases (ILDs) are pathologies affecting the pulmonary interstitium and, less frequently, the alveolar and vascular epithelia. Bronchoalveolar lavage (BAL) is commonly used in ILD evaluation since it allows the sampling of the lower respiratory tract. The prognostic value of BAL cell counts in ILD is unknown.
View Article and Find Full Text PDFComparison between Immunoglobulin G4-Related Eye Disease and Other Entities with Non-Immunoglobulin G4 Ocular Involvement.
Eur J Rheumatol
July 2024
Department of Rheumatology, Hospital J.M. Cullen, Santa Fe, Argentina.
Article Synopsis
- The study aimed to differentiate IgG4-related ocular disease (IgG4-ROD) from non-IgG4 ocular diseases by examining various clinical and analytical features.
- It involved 18 patients with IgG4-ROD and 12 with other inflammatory or autoimmune conditions, comparing demographic profiles and symptoms like proptosis and diplopia.
- Results showed a higher prevalence of specific symptoms like proptosis and xerophthalmia in IgG4-ROD, with significant associations found between certain features and the disease type.
Concordance between clinical diagnoses and autopsies anatomopathological findings at a tertiary-level university hospital.
Biomedica
November 2024
Departamento de Patología, Universidad de Cartagena, Cartagena de Indias, Colombia.
Introduction: A clinical autopsy is a fundamental diagnostic tool for confirming the diagnosis of diseases of public health interest. However, the clinical-pathological concordance has not been evaluated.
Objective: To determine the concordance between clinical diagnoses and anatomopathological findings from autopsies conducted at a tertiary-level hospital institution.
Primitive Resectable Small Bowel Cancer Clinical-Pathological Analysis: A 10-Year Retrospective Study in a General Surgery Unit.
Cancers (Basel)
November 2024
Gastroenterology Department, University of Medicine and Pharmacy, 200349 Craiova, Romania.
Small bowel cancer is very rare; although the incidence of adenocarcinoma and other anatomopathological forms has increased recently, the diagnosis and treatment of this disease are still debatable because of the clinical heterogeneity and the absence of studies including a large number of patients. We performed a retrospective study over 10 years in which we analyzed the clinical, imaging, and anatomopathological data of 46 patients hospitalized in a surgery clinic and diagnosed with small bowel cancer (duodenum, jejunum, and ileum). After clinical assessment of these patients, including complications (occlusion, bleeding, and perforation), the CT scan established the diagnosis in over 90% of the cases of the complicated form of the disease.
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