Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0026-0495(68)90095-4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Risk impact of SARS-CoV-2 coronavirus and spike protein on cardiac tissue: a comprehensive review.
Physiol Res
December 2024
Laboratory of Neurobiology and Molecular Psychiatry, Department of Biochemistry, Faculty of Science, Masaryk University, Brno, Czech Republic.
The global COVID-19 pandemic, caused by SARS-CoV-2, has led to significant morbidity and mortality, with a profound impact on cardiovascular health. This review investigates the mechanisms of SARS-CoV-2's interaction with cardiac tissue, particularly emphasizing the role of the Spike protein and ACE2 receptor in facilitating viral entry and subsequent cardiac complications. We dissect the structural features of the virus, its interactions with host cell receptors, and the resulting pathophysiological changes in the heart.
View Article and Find Full Text PDFHigh glucose potentiates Zika virus induced-astroglial dysfunctions.
J Neurovirol
December 2024
Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Zika virus (ZIKV) is a neurotropic flavivirus that induces congenital Zika syndrome and neurodevelopmental disorders. Given that ZIKV can infect and replicate in neural cells, neurological complications in adult brain are also observed. Glial cells may emerge to delay and/or prevent the development of ZIKV-induced neurodegeneration.
View Article and Find Full Text PDFCharacterization of immortalized human podocytes infected with lentivirus as an model of viral infection-associated podocytopathy.
Am J Clin Exp Immunol
October 2024
National Clinical Research Center for Kidney Diseases, Jinling Hospital, Medical School of Nanjing University Nanjing 210002, Jiangsu, China.
Article Synopsis
- Studies show kidney disease is linked to viral infections, causing kidney injury through systemic inflammation and direct infection of kidney cells.
- Research using an immortalized human podocyte cell line (HPC) infected with lentivirus revealed strong immune responses and pathways related to cell death, indicating compromised cell viability.
- The findings suggest that these lentivirus-infected HPC cells serve as a valuable model for studying how viral infections specifically damage podocytes, separate from other stressors like Adriamycin.
High prevalence of long COVID in anti-TPO positive euthyroid individuals with strongly elevated SARS-CoV-2-specific T cell responses and moderately raised anti-spike IgG levels 23 months post-infection.
Front Immunol
October 2024
Department of Hematology and Stem Cell Transplantation, Central Hospital of Southern Pest, National Institute of Hematology and Infectious Diseases, Budapest, Hungary.
Introduction: Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection, the causative agent of coronavirus disease 2019 (COVID-19), causes post-acute infection syndrome in a surprisingly large number of cases worldwide. This condition, also known as long COVID or post-acute sequelae of COVID-19, is characterized by extremely complex symptoms and pathology. There is a growing consensus that this condition is a consequence of virus-induced immune activation and the inflammatory cascade, with its prolonged duration caused by a persistent virus reservoir.
View Article and Find Full Text PDFCOVID-19 Therapeutics Why Not Angiotensin Receptor Blockers (ARBs)?
J Assoc Physicians India
November 2023
Professor of Pharmacology Retired, MOSC Medical College, Kolenchery, Kerala, India, Corresponding Author.
Overactivity of the renin-angiotensin-aldosterone system (RAAS) is a consistent feature of COVID-19 as indicated by high concentrations of angiotensin II (Ang II) in lungs and other tissues. Virus-induced downregulation of angiotensin-converting enzyme-2 (ACE2) explains the raised Ang II levels. Available evidence points to the crucial role of Ang II in the pathogenesis of coronavirus disease.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!