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Assessment of the impact of HIV infection on the hypothalamic-pituitary-ovarian axis and pubertal development among adolescent girls at a tertiary centre in Zimbabwe: a cross-sectional study.
BMC Endocr Disord
January 2025
Faculty of Medicine and Health Sciences, Department of Obstetrics and Gynaecology, University of Zimbabwe, P. O. Box A178, Avondale, Harare, Zimbabwe.
Background: Proper planning of reproductive health needs for HIV-infected adolescents requires a clear understanding of the effects of HIV infection on adolescents' pubertal development.
Objective: To assess the effects of HIV infection on the hypothalamic-pituitary-ovarian (HPO) axis, ovarian reserve and pubertal development in adolescent girls at a tertiary hospital in Zimbabwe.
Methods: This was a cross-sectional survey of HIV-infected adolescent girls aged 10-19 years, with available CD4 + count results at a tertiary hospital in Zimbabwe.
Impact of psychological stress on ovarian function: Insights, mechanisms and intervention strategies (Review).
Int J Mol Med
February 2025
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.
Mental stress may lead to ovarian dysfunction. Psychological stress disrupts ovarian function, leading to adverse fertilization outcomes, premature ovarian insufficiency and decreased ovarian reserve. Furthermore, psychological stress caused by decreased ovarian function and infertility can exacerbate the mental burden.
View Article and Find Full Text PDFThe relationship between psychological stress and ovulatory disorders and its molecular mechanisms: a narrative review.
J Psychosom Obstet Gynaecol
December 2024
Assisted Reproduction Unit, Department of Gynecology and Obstetrics, Sir Run Run Shaw Hospital, Hangzhou, China.
This narrative review explores the relationship between psychological stress and ovulatory disorders, focusing on the molecular mechanisms involved. Ovulation is regulated by the hypothalamus-pituitary-ovarian (HPO) axis, and disruptions in this axis can lead to ovulatory dysfunction. Chronic psychological stress affects the HPO axis, resulting in abnormalities in hypothalamus hormone secretion, pituitary hormone release, and ovarian function.
View Article and Find Full Text PDFDiagnosis of hypoprolactinemia.
Rev Endocr Metab Disord
December 2024
Department of Endocrinology, Erciyes University Medical School, Kayseri, Turkey.
Prolactin is a polypeptide hormone composed of 199 amino acids, synthesized by lactotroph cells. Its primary effects are on the mammary gland and gonadal axes, but it also influences different organs and systems, particularly metabolic functions. Current literature has mainly focused on the diagnosis, monitoring, and treatment of hyperprolactinemia.
View Article and Find Full Text PDFSubacute exposure to a mixture of tributyltin plus mercury impairs reproductive axis function, exacerbating premature ovarian insufficiency features and reducing fertility in female rats.
Reprod Toxicol
October 2024
Department of Morphology, Federal University of Espírito Santo, Vitória 290440-090, Brazil. Electronic address:
Tributyltin (TBT) and mercury (Hg) are endocrine-disrupting chemicals that individually cause reproductive complications. However, the reproductive consequences of exposure to a mixture of TBT plus Hg are not well known. We hypothesized that exposure to a mixture of TBT plus Hg would alter hypothalamic-pituitary-gonadal (HPG) axis function.
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