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BMP4 regulates differentiation of nestin-positive stem cells into melanocytes.
Cell Mol Life Sci
January 2025
Department of Anesthesiology, Shenzhen Children's Hospital, Yitian Road 7019, Shenzhen, 518000, China.
Hair follicle (HF) development and pigmentation are complex processes governed by various signaling pathways, such as TGF-β and FGF signaling pathways. Nestin + (neural crest like) stem cells are also expressed in HF stem cells, particularly in the bulge and dermal papilla region. However, the specific role and differentiation potential of these Nestin-positive cells within the HF remain unclear, especially regarding their contribution to melanocyte formation and hair pigmentation.
View Article and Find Full Text PDFA sensory neuroprosthesis enhances recovery from treadmill-induced stumbles for individuals with lower limb loss.
Sci Rep
January 2025
Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA.
Over 50% of individuals with lower limb loss report a fear of falling and avoiding daily activities partly due to a lack of plantar sensation. Providing direct somatosensory feedback via neural stimulation holds promise for addressing this issue. In this study, three individuals with lower limb loss received a sensory neuroprosthesis (SNP) that provided plantar somatosensory feedback corresponding to prosthesis-floor interactions perceived as arising from the missing foot generated by electrically activating the peripheral nerves in the residuum.
View Article and Find Full Text PDFEarly life stress and functional connectivity in antipsychotic-naïve first episode psychosis patients.
Schizophrenia (Heidelb)
January 2025
Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL, USA.
The neural mechanisms underlying the association between childhood trauma (CT) and psychosis spectrum disorders remains unclear. The objective of this study is to examine the relationship between childhood trauma and functional connectivity of fronto-limbic regions in a large sample of antipsychotic-naïve patients with first episode psychosis (FEP). Resting state fMRI data from 105 FEP patients and 123 healthy controls (HC) were used.
View Article and Find Full Text PDFLeft-Right Brain-Wide Asymmetry of Neuroanatomy in the Mouse Brain.
Neuroimage
January 2025
Department of Genetics, Harvard Medical School, Boston, MA, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA. Electronic address:
Left-right asymmetry of the human brain is widespread through its anatomy and function. However, limited microscopic understanding of it exists, particularly for anatomical asymmetry where there are few well-established animal models. In humans, most brain regions show subtle, population-average regional asymmetries in thickness or surface area, alongside a macro-scale twisting called the cerebral petalia in which the right hemisphere protrudes anteriorly past the left.
View Article and Find Full Text PDFRight Inferior Frontal Cortex and preSMA in Response Inhibition: An Investigation Based on PTC Model.
Neuroimage
January 2025
Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. Electronic address:
Response inhibition is an essential component of cognitive function. A large body of literature has used neuroimaging data to uncover the neural architecture that regulates inhibitory control in general and movement cancelation. The presupplementary motor area (preSMA) and the right inferior frontal cortex (rIFC) are the key nodes in the inhibitory control network.
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