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The Influence of Sex, Fitness, BMI, and Cardiovascular Risk Factors on Cerebral Blood Velocity Responsiveness to Graded Exercise Testing in Middle-Aged Adults.
J Gerontol A Biol Sci Med Sci
December 2024
GENUD Toledo Research Group, Faculty of Sport Sciences, University of Castilla-La Mancha, Toledo, Spain.
Mean middle cerebral artery velocity (MCAv) and the pulsatility index (PI), at rest and in response to exercise, are important markers of cerebrovascular health status in middle-aged adults, when vascular decline assumes substantial relevance. Thus, this study aimed to describe and compare the responses of MCAv and PI to incremental exercise. Two hundred and forty-eight volunteers (50-58 years, 55% women) completed a ramp test on a cycle-ergometer.
View Article and Find Full Text PDFThe effects of aerobic exercise and heat stress on the unbound fraction of caffeine.
Front Physiol
January 2025
Human Physiology Research Unit, Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, Canada.
Introduction: The fraction of drug circulating in the blood that is not bound to plasma proteins ( ) is considered pharmacologically active since it readily binds to its receptor. evidence suggests that changes in temperature and pH affect the affinity of drug binding to plasma proteins, resulting in changes in . In light of the well-established effects of exercise on body temperature and blood pH, we investigated whether an increase in blood temperature and decrease in pH facilitated through passive heating and exercise translated to a change in the of caffeine.
View Article and Find Full Text PDFAxial length to corneal curvature radius ratio is negatively correlated with choroidal blood flow in myopic children.
Front Ophthalmol (Lausanne)
January 2025
Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Background: The pathophysiologic mechanisms underlying early-onset myopia remain unclear; in this study, we investigate the pathogenesis by examining the interrelationships between axial length to corneal curvature radius ratio ( ) and choroidal blood flow.
Methods: This cross-sectional study included 202 eyes from myopic children, categorized into 141 eyes with mild myopia, 47 eyes with moderate myopia, and 14 eyes with high myopia. Optical coherence tomography angiography (OCTA) was used to measure choroidal blood flow perfusion within a 6 mm × 6 mm area of the macular region, divided into nine subareas based on ETDRS partitioning: macular fovea, nasal side 1, superior 1, temporal side 1, inferior 1, nasal side 2, superior 2, temporal side 2, and inferior 2.
Circulating growth differentiation factor-15 levels are associated with early echocardiographic signs of diastolic function impairment in the STANISLAS cohort: A 20-year follow-up study.
Eur J Heart Fail
January 2025
Université de Lorraine, INSERM, Centre d'Investigations Cliniques Plurithématique 1433, Inserm U1116, CHRU de Nancy and F-CRIN INI-CRCT, Nancy, France.
Aims: Early identification of healthy subjects prone to develop cardiac dysfunction may be instrumental to prevention strategies. Our study aimed to evaluate whether circulating levels of growth differentiation factor-15 (GDF-15) could predict adverse changes in echocardiographic indexes of cardiac structure and function in an initially healthy populational familial cohort with a long follow-up (STANISLAS cohort).
Methods And Results: We evaluated 1679 participants (49 ± 14 years, 48% males) included in the fourth visit (V4) of the STANISLAS cohort with available GDF-15 measurements (Olink proteomic analysis) and echocardiographic parameters.
Seasonal forecasting of East African short rains.
Sci Rep
January 2025
Department of Biological, Geological, and Environmental Sciences, University of Bologna, Bologna, Italy.
The variability of East African short rains (October-December) has profound socioeconomic and environmental impacts on the region, making accurate seasonal rainfall predictions essential. We evaluated the predictability of East African short rains using model ensembles from the multi-system seasonal retrospective forecasts from the Copernicus Climate Change Service (C3S). We assess the prediction skill for 1- to 5-month lead times using forecasts initialized in September for each year from 1993 to 2016.
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