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This article describes the first experience of successful use of growth hormone (GH) in combination with an aromatase inhibitor (AI), in a 14-year-old boy. At the age of 7, he presented with headaches, nausea and vomiting, and MRI revealed a craniopharyngioma (CP). An Ommaya system was implanted, and radiation therapy was performed.
View Article and Find Full Text PDFCancer screening in patients with acromegaly: a plea for a personalized approach and international registries.
Rev Endocr Metab Disord
March 2025
Dipartimento Di Medicina Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.
Acromegaly is a rare condition, and often diagnosis is delayed by several years, for most patients. Acromegaly is characterized by short and long-term respiratory, cardiovascular and metabolic comorbidities, with possible impact on mortality. In the last two decades, life expectancy has progressively increased in part due to a reduction in biochemically active disease, multidisciplinary treatment approaches and a reduction in complications, and the availability of new drugs.
View Article and Find Full Text PDFIncidental High-Grade Sellar Solitary Fibrous Tumor Mimicking Non-Functioning Pituitary Adenoma: A Case Report and Literature Review.
Am J Case Rep
March 2025
Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA, USA.
BACKGROUND Sellar solitary fibrous tumors (SFT) are uncommon brain tumors belonging to the fibroblastic and myofibroblastic category of the 2021 World Health Organization (WHO) Classification of Central Nervous System (CNS) Tumors. Twenty-two instances of sellar WHO grade II and III SFT (SFT II/III) have been reported since 1983. SFTs II/III clinical and imaging findings resemble non-functioning pituitary adenomas (NFPAs).
View Article and Find Full Text PDFDual-channel compression mapping network with fused attention mechanism for medical image segmentation.
Sci Rep
March 2025
College of Mechanical Engineering, Quzhou University, Quzhou, 324000, China.
Accurate image segmentation is the key to quantitative analysis and recognition of pathological tissues in medical imaging technology, which can provide important technical support for medical diagnosis and treatment. However, the task of lesion segmentation is particularly challenging due to the difficulty in identifying edges, the complexity of different tissues, and the variability in their shapes. To address these challenges, we propose a dual-channel compression mapping network (DCM-Net) with fused attention mechanism for medical image segmentation.
View Article and Find Full Text PDFA contemporary, multiinstitutional analysis of transcription factor lineage in pituitary adenomas: comparative study of neuroimaging, histopathology, and clinical outcomes.
J Neurosurg
March 2025
1Department of Neurological Surgery, University of Southern California, Keck School of Medicine, Los Angeles, California.
Objective: Pituitary adenomas (PAs) are common lesions that often present with endocrinopathy and/or visual symptoms. Classification of PAs has historically been based on functional status and histopathological staining of anterior pituitary hormones. In 2017, the WHO revised the classification of PAs, establishing cell lineages identified by the transcription factors (TFs) PIT1, TPIT, and SF1.
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