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Real-World Long-Term Effectiveness of Implantable Cardioverter-Defibrillators in Elderly Patients.
Circ Rep
January 2025
Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University Sapporo Japan.
Background: Because it is unclear whether implantable cardioverter-defibrillators (ICDs) are equally effective in patients of all ages, we investigated the association of age with long-term clinical outcomes of patients who underwent ICD implantation.
Methods And Results: A total of 416 consecutive patients (mean age: 69 years) from 4 tertiary hospitals who underwent ICD implantation or were upgraded from an existing permanent pacemaker between January 2011 and November 2022 were enrolled and divided into 3 groups based on age: <65 years (n=158), 65-74 years (n=138), and ≥75 years (n=120). We compared the incidence of all-cause death and adverse cardiovascular events, including cardiac death, appropriate ICD therapy, and heart failure hospitalization.
Outcomes of permanent pacemakers and implantable cardioverter-defibrillators in an adult congenital heart disease population.
Int J Cardiol Congenit Heart Dis
March 2024
Sydney Medical School, The University of Sydney, Camperdown, Australia.
Background: Brady- and tachyarrhythmias commonly complicate adult congenital heart disease (ACHD). Permanent pacemakers (PPMs) or implantable cardioverter-defibrillators (ICDs) are often utilised to prevent morbidity or mortality related to arrhythmia, but can also be associated with significant morbidity themselves.
Methods: We analysed outcomes from patients in our comprehensive ACHD database who were seen at least twice since 2000 and once since 2018.
Patient Preferences for Features Associated With Leadless Versus Conventional Transvenous Cardiac Pacemakers.
Circ Cardiovasc Qual Outcomes
December 2024
Duke Clinical Research Institute (S.D.R., J.-C.Y., M.J.W., J.S., F.R.J., S.O., S.M.A.-K.), Duke University School of Medicine, Durham, NC.
Article Synopsis
- A study examined patient preferences for different types of pacemakers, including new dual-chamber leadless options and traditional transvenous ones, to identify which features are most important to them.
- Surveying 117 patients, researchers found that half preferred leadless pacemakers while the other half favored conventional ones, highlighting a significant division in choices.
- Key factors influencing patient decisions included preferred pacemaker type, acceptance of complication and infection risks, and the time since regulatory approval, with many willing to accept higher risks for their preferred options.
A phenotypic comparison of the Romanian and French ATTRv cohorts: Glu54Gln founder pathogenic variant vs the most common variants in Western Europe.
Int J Cardiol
January 2025
French Referral Centre for Cardiac Amyloidosis, GRC Amyloid Research Institute, Amyloidosis Mondor Network, Henri-Mondor Teaching Hospital, AP-HP, Creteil, France; Cardiology Department, Henri-Mondor Teaching Hospital, Creteil, France; Clinical Epidemiology and Ageing (CEpiA) Geriatrics, Primary Care and Public Health, Creteil, France; Université Paris Est Creteil, INSERM, IMRB, Creteil, France.
Aim And Methods: We conducted a retrospective observational study of the ATTRv heterozygous mutation frequency, phenotype, and all-cause mortality at two cardiac amyloidosis centers in Romania and France.
Results: 291 patients were included: 26 Glu54Gln (all Romanian), 200 Val122Ile, 47 Val30Met and 18 Ser77Tyr. On diagnosis, Gu54Gln patients were younger than Val122Ile or late-onset Val30Met (median age: 46 [42-50], 76 [71-80] and 70 [61-76], respectively; p < 0.
Diagnosis and treatment of 2 cases with cryptogenic stroke due to patent foramen ovale in children: A case report.
Medicine (Baltimore)
October 2024
Department of Cardiology, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Article Synopsis
- Arterial ischemic stroke occurs when brain tissue dies due to inadequate blood supply; about 30% of these cases are classified as cryptogenic strokes with unknown causes.
- Two young female patients were diagnosed with cryptogenic strokes and were found to have patent foramen ovale (PFO) as a potential cause after excluding other factors.
- Both patients underwent PFO closure; the first child experienced symptom relief after the procedure, while the second showed improvement in neurologic symptoms following the same intervention.
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