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Methylated magnetic covalent organic framework for sample preparation and LC-MS/MS detection of 12 tadalafil analogs in dietary supplements.
J Chromatogr B Analyt Technol Biomed Life Sci
December 2024
Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing 100176, China; Key Laboratory of Food Quality and Safety, State Administration for Market Regulation, Beijing 100176, China. Electronic address:
Tadalafil analogs are often illegally added to dietary supplements such as herbal beverages, protein powders and tablet foods. Due to the complexity of the matrices, effective extraction of tadalafil analogs is the key to achieve accurate quantification. Therefore, it is of great significance to establish a rapid and effective method for the analytical determination of tadalafil analogs in complex matrices.
View Article and Find Full Text PDFNovel eco-friendly HPTLC method using dual-wavelength detection for simultaneous quantification of duloxetine and tadalafil with greenness evaluation and application in human plasma.
Sci Rep
October 2024
Analytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt.
Article Synopsis
- A novel and eco-friendly HPTLC method has been created to measure duloxetine (DLX) and tadalafil (TDL), which is beneficial for treating depression and sexual issues in patients.
- The method uses a specific stationary phase and mobile phase for effective separation, allowing for precise quantification of both drugs in pure forms and human plasma with very low detection limits.
- Validation of the method followed international guidelines, and its environmental impact was evaluated using several green chemistry assessment tools, confirming its sustainability and practicality.
Presence of Flazin in Miso and Identification of Four Tryptophan-Derived ß-Carbolines Formed during Fermentation.
J Agric Food Chem
September 2024
Department of Food Science, National Chiayi University, Chiayi 60004, Taiwan, ROC.
In miso, due to the substantial presence of genistein, flazin is often overlapped and masked by genistein in HPLC analysis. Flazin in the miso extracts could be resolved with genistein through medium-pressure liquid chromatography run under a nonacidified methanol-water system and subsequently fractionated by semipreparative HPLC and identified by NMR spectroscopic analysis. As referenced, flazin was detected in all 11 locally marketed miso products, with contents ranging from 3.
View Article and Find Full Text PDFDevelopment of a simultaneous analytical method for the dietary exposure determination of β-Carboline alkaloids in foods.
Food Chem
December 2024
Doping Control Center, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea. Electronic address:
As β-carboline (βC) alkaloids, posing potential health risks, are present in a wide variety of foods, determining the exposure degrees of food to these alkaloids from dietary activity is key to ensuring food safety. Here, we developed a rapid and sensitive simultaneous analytical method for six βC alkaloids in food. We optimized the buffered QuEChERS method, which includes a clean-up process through dispersive solid phase extraction, to extract the target compounds from food matrices; then, these compounds were detected via liquid chromatography-tandem mass spectrometry.
View Article and Find Full Text PDFThe Inhibitory Effects of the Herbals Secondary Metabolites (7α-acetoxyroyleanone, Curzerene, Incensole, Harmaline, and Cannabidiol) on COVID-19: A Molecular Docking Study.
Recent Pat Biotechnol
May 2024
Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Box 71468-64685, Shiraz, Iran.
Background: Since the COVID-19 outbreak in early 2020, researchers and studies are continuing to find drugs and/or vaccines against the disease. As shown before, medicinal plants can be very good sources against viruses because of their secondary compounds which may cure diseases and help in survival of patients. There is a growing trend in the filed patents in this field.
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