A method is described whereby lignocaine can be measured in small samples of canine myocardium. A proteolytic enzyme is used to digest the tissue, and the drug, together with an internal standard, is subsequently extracted into an organic solvent and measured by gas-liquid chromatography. The method is reproducible using tissue samples as small as 50 mg and appears to be suitable for the measurement of a number of drugs in small samples of tissue.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1145626 | PMC |
| http://dx.doi.org/10.1136/jcp.32.3.225 | DOI Listing |
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