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Surpassing protein specificity in biomimetics of bacterial amyloids.
Int J Biol Macromol
January 2025
Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, Barcelona, Spain; Departament de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, Barcelona, Spain; Institut de Recerca Sant Pau (IR SANT PAU), 08041 Barcelona, Spain. Electronic address:
In nature, nontoxic protein amyloids serve as dynamic, protein-specific depots, exemplified by both bacterial inclusion bodies and secretory granules from the endocrine system. Inspired by these systems, chemically defined and regulatory-compliant artificial protein microgranules have been developed for clinical applications as endocrine-like protein repositories. This has been achieved by exploiting the reversible coordination between histidine residues and divalent cations such as Zn, that promotes protein-protein interactions.
View Article and Find Full Text PDFEnzymatic Synthesis of Biologically Active -Phosphinic Analogue of α-Ketoglutarate.
Biomolecules
December 2024
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov St., 32, 119991 Moscow, Russia.
Amino acid analogues with a phosphorus-containing moiety replacing the carboxylic group are promising sources of biologically active compounds. The -phosphinic group, with hydrogen-phosphorus-carbon (H-P-C) bonds and a flattened tetrahedral configuration, is a bioisostere of the carboxylic group. Consequently, amino--phosphinic acids undergo substrate-like enzymatic transformations, leading to new biologically active metabolites.
View Article and Find Full Text PDFChiral nanoenzymes: synthesis and applications.
Mikrochim Acta
November 2024
College of Petrochemical Technology, Lanzhou University of Technology, 730050, Lanzhou, P.R. China.
Article Synopsis
- Chiral nanoenzymes are innovative materials that combine chiral nanostructures with enzymatic catalytic activity, providing unique selectivity in biological processes.
- They offer benefits over natural enzymes due to their strong stereospecificity, biocompatibility, and diverse applications in fields like medicine, biosensing, and environmental protection.
- Recent research has focused on the design, development, and practical uses of chiral nanoenzymes, along with the challenges and future directions in this area.
Chemoenzymatic Synthesis of Phosphosaccharides from Strains ER-6P (Serovar 15) and Nagasaki (Serovar 5).
Org Lett
November 2024
Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao 266237, China.
Herein, we describe a chemoenzymatic and diversity-oriented approach for the first syntheses of octasaccharide repeating units of the capsular polysaccharides of serovar 15 and serovar 5. The synthetic method features efficient enzymatic assembly of sialyl galactose or -acetyl-galactosamine building blocks, highly stereoselective chemical construction of α-type -phosphonate, and the β-stereospecific 1,3-glycosylation reaction of a rare sugar donor.
View Article and Find Full Text PDFMammalian D-Cysteine controls insulin secretion in the pancreas.
Mol Metab
December 2024
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Article Synopsis
- - D-amino acids, particularly D-cysteine, are gaining recognition for their role in the mammalian pancreas, with D-cysteine synthesized by the enzyme serine racemase (SR), leading to significantly higher insulin levels in SR mice.
- - In diabetic mouse models, D-cysteine levels increase compared to D-serine, along with higher expression of SR, which affects insulin secretion regulation and DNA methylation patterns in pancreatic cells.
- - Dietary methyl donor supplementation can restore normal insulin levels and decrease certain enzymatic activities in SR mice, indicating that D-cysteine is a crucial regulator of insulin secretion in the pancreas.
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