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Polyamine Pathway Inhibitor DENSPM Suppresses Lipid Metabolism in Pheochromocytoma Cell Line.
Int J Mol Sci
September 2024
Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 03610, USA.
Pheochromocytomas (PCCs) are tumors arising from chromaffin cells in the adrenal medulla, and paragangliomas (PGLs) are tumors derived from extra-adrenal sympathetic or parasympathetic paraganglia; these tumors are collectively referred to as PPGL cancer. Treatment for PPGL primarily involves surgical removal of the tumor, and only limited options are available for treatment of the disease once it becomes metastatic. Human carriers of the heterozygous mutations in the succinate dehydrogenase subunit B () gene are susceptible to the development of PPGL.
View Article and Find Full Text PDF24-hour urine metanephrine excretion in patients diagnosed with adrenal incidentaloma: impact of commonly used drugs on a clinical decision.
Pol Arch Intern Med
March 2024
Department of Endocrinology, Jagiellonian University Medical College, Kraków, Poland
Introduction: Incidentaloma is an adrenal tumor detected during diagnostic imaging performed for extra‑adrenal causes. Evaluation of metanephrine concentrations in a 24‑hour urine collection can be a significant challenge in patients with multiple medications and comorbidities.
Objectives: The aim of this study was to evaluate the effect of commonly used groups of drugs on metanephrine levels in the 24‑hour urine collection.
Levodopa-Induced Pseudopheochromocytoma.
Eur J Case Rep Intern Med
May 2023
Hospital da Horta, Azores, Portugal.
Unlabelled: Pseudopheochromocytoma is a pathological condition presenting with paroxysmal hypertension with normal or moderate elevation in catecholamines and metanephrine levels, but no evidence of a tumoural cause. Imaging studies and I-123 metaiodobenzylguanidine scintigraphy are essential for exclusion of pheocromocytoma. We describe a case of pseudopheochromocytoma related to levodopa in a patient with paroxysmal hypertension, headache, sweating, palpitations and increased plasmatic and urinary metanephrine levels, without adrenal or extra-adrenal tumour.
View Article and Find Full Text PDFColon cancer cells produce immunoregulatory glucocorticoids.
Oncogene
May 2011
Division of Experimental Pathology, Institute of Pathology, University of Bern, Bern, Switzerland.
Glucocorticoids (GC) have important anti-inflammatory and pro-apoptotic activities. Initially thought to be exclusively produced by the adrenal glands, there is now increasing evidence for extra-adrenal sources of GCs. We have previously shown that the intestinal epithelium produces immunoregulatory GCs and that intestinal steroidogenesis is regulated by the nuclear receptor liver receptor homolog-1 (LRH-1).
View Article and Find Full Text PDFMalignant pheochromocytomas and paragangliomas - the importance of a multidisciplinary approach.
Cancer Treat Rev
April 2011
Department of Clinical Physiology and Nuclear Medicine, Herlev Hospital, University Hospital of Copenhagen, DK-2730 Herlev, Denmark.
Approximately 10% of the pheochromocytomas and 20% of the paragangliomas are malignant with poor survival. As the biological behaviour of these tumours cannot be predicted with certainty from pathology the diagnosis of malignancy is difficult. Genetic testing is gaining impact as mutations in the tumour suppressor gene Von Hippel-Lindau and the mitochondrial succinate dehydrogenase enzyme complex subunit B (SDHB) are associated with malignancy.
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