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Modelling the seasonal dynamics of Aedes albopictus populations using a spatio-temporal stacked machine learning model.
Sci Rep
January 2025
Center Agriculture Food Environment, University of Trento, San Michele all'Adige, Italy.
Various modelling techniques are available to understand the temporal and spatial variations of the phenology of species. Scientists often rely on correlative models, which establish a statistical relationship between a response variable (such as species abundance or presence-absence) and a set of predominantly abiotic covariates. The choice of the modeling approach, i.
View Article and Find Full Text PDFIs Bone Cement Implantation Syndrome Actually Caused by Cement? A Systematic Review of the Literature Using the Bradford-Hill Criteria.
J Arthroplasty
January 2025
Department of Orthopaedic Surgery, University of Virginia, 2280 Ivy Road, Charlottesville, VA, 22903, United States of America.
Introduction: Debate surrounding the use of cemented femoral components in hip arthroplasty persists. A proposed risk of cement fixation is bone cement implantation syndrome (BCIS), a phenomenon characterized by intraoperative hypotension, hypoxia, and/or cardiovascular collapse. The purpose of this study was to analyze the literature to determine if enough evidence exists to support a causal relationship between cement and BCIS.
View Article and Find Full Text PDFMaternal immune activation alters the GABAergic system in the prefrontal cortex of female rat offspring: Role of interleukin-6.
Neuroscience
January 2025
Department of Physiology, College of Medicine, Health Sciences Centre, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait. Electronic address:
Maternal immune activation (MIA) induces long-term cognitive impairments by modulating the gamma-aminobutyric acid (GABA)ergic system. Experimental evidence suggests that maternal immune challenge with bacterial active ingredient lipopolysaccharide (LPS) reduces GABAergic tone in the offspring's prefrontal cortex. In this study, we aimed to assess whether interleukin-6 (IL-6) contributes to this reduced GABAergic system in the prefrontal cortex of juvenile offspring.
View Article and Find Full Text PDFDamage sensing through TLR9 regulates inflammatory and antiviral responses during influenza infection.
Mucosal Immunol
January 2025
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh Medical Center Pittsburgh PA USA; Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine New Haven CT USA. Electronic address:
Host response aimed at eliminating the infecting pathogen, as well as the pathogen itself, can cause tissue injury. Tissue injury leads to the release of a myriad of cellular components including mitochondrial DNA, which the host senses through pattern recognition receptors. How the sensing of tissue injury by the host shapes the anti-pathogen response remains poorly understood.
View Article and Find Full Text PDFThermodynamic binding properties of a novel umami octapeptide KADEDSLA and its mutational variants p.A2G, p.D5E, and p.A2G + p.D5E (BMP) in complex with the umami receptor hT1R1/hT1R3.
Food Chem
January 2025
Department of Bioengineering, Faculty of Chemical and Metallurgical Engineering, Yildiz Technical University, İstanbul 34210, Türkiye; Health Biotechnology Joint Research and Application Center of Excellence, Istanbul 34903, Türkiye. Electronic address:
Umami taste properties of a novel octameric peptide KADEDSLA and its mutants p.A2G, p.D5E, and BMP (KGDEESLA, beef meaty peptide) were assessed by molecular docking, and molecular dynamics (MD) (>1 μsec), MM-PBSA, and Mutational Affinity Prediction (MAP) methods.
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