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Cyclosporine A causes gingival overgrowth via reduced G1 cell cycle arrest in gingival fibroblasts.
PLoS One
December 2024
Department of Biochemistry and Molecular Biology, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba, Japan.
Gingival overgrowth caused by cyclosporine A is due to increased fibroblast proliferation in gingival tissues. Cell cycle system balances proliferation and anti-proliferation of gingival fibroblasts and plays a role in the maintenance of its population in gingival tissues. When cells detect and respond to abnormalities (e.
View Article and Find Full Text PDFHSPA4 Enhances BRSV Entry via Clathrin-Mediated Endocytosis Through Regulating the PI3K-Akt Signaling Pathway and ATPase Activity of HSC70.
Viruses
November 2024
Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China.
Bovine respiratory syncytial virus (BRSV) is an enveloped RNA virus that utilizes clathrin-mediated endocytosis for cell entry and is a significant pathogen in bovine respiratory disease (BRD). Heat shock protein family A member 4 (HSPA4), a member of the HSP70 family, is known to be involved in the progression of various cancers. However, its role in virus entry has not been previously explored.
View Article and Find Full Text PDFAffects Milk Protein Content by Regulating Amino Acid Transporters and the PI3K-Akt, WNT, and mTOR Signaling Pathways.
Genes (Basel)
November 2024
Shandong Provincial Key Laboratory for Livestock Germplasm Innovation & Utilization, College of Animal Science, Shandong Agricultural University, Tai'an 271018, China.
Background: Calgranulin B () was found to be strongly associated with milk protein percentage in dairy cattle in our previous genome-wide association study.
Methods: SNPs in were identified via pooled sequencing, and genotyping of 1054 cows was performed individually using MassArray with MALDI-TOFMS technology. Association analyses between the SNPs and five milk production traits were conducted using SAS 9.
Brevibacterium enzymes as biological tools for ochratoxin A detoxification in dairy foods.
Int J Food Microbiol
January 2025
Instituto de Ciencia y Tecnología de Alimentos y Nutrición (ICTAN), CSIC, José Antonio Novais 6, 28040 Madrid, Spain. Electronic address:
The origin of ochratoxin A (OTA) in cheeses is mainly due to mould growth during the ripening process, and to a lesser extent, to the use of OTA-contaminated milk in cheese production. Bacterial smear-ripened cheeses developed a smear microbiota on their rind during ripening that greatly contributes to its typical aroma and texture. Bacteria from the Brevibacterium genus belong to the typical smear microbiota of cheeses.
View Article and Find Full Text PDFTrivalent Chromium Ameliorates Lipid Accumulation and Enhances Glucose Metabolism in the High-NEFA Environment of Bovine Hepatocytes by Regulating PI3K/AKT Pathways.
J Agric Food Chem
December 2024
College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang, Shaanxi 712100, China.
During the periparturient transition period, dairy cows are often accompanied by disorders of liver glycolipid metabolism. The PI3K/AKT signaling pathway plays an important role in the homeostasis of glycolipid metabolism. Trivalent chromium [Cr(III)] is an essential trace element in the body.
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