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Beneficial Effects of the Herbal Medicine Zuo Gui Wan in a Mice Model of Alzheimer's Disease via Drp1-Mediated Inhibition of Mitochondrial Fission and Activation of AMPK/PGC-1α-regulated Mitochondrial Bioenergetics.
J Ethnopharmacol
January 2025
School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address:
Ethnopharmacological Relevance: Zuo Gui Wan (ZGW) is a well-known traditional Chinese medicine decoction used for approximately 400 years to treat age-related degenerative conditions, including cognitive impairment in older adults, osteoporosis, and general aging. However, the mechanism of action for ZGW remains unclear.
Aims Of The Study: This study aims to investigate the efficacy of ZGW in improving cognitive function in Alzheimer's disease (AD) animal models and to explore the underlying mechanisms, presenting a novel perspective in the field.
Modular Metabolic Engineering of for Enhanced Production of Ursolic Acid.
J Agric Food Chem
January 2025
State Key Laboratory of Synthetic Biology, School of Chemical Engineering and Technology, Tianjin University, Yaguan Road 135, Jinnan District, Tianjin 300350, China.
Ursolic acid, a plant-derived pentacyclic triterpenoid with anti-inflammatory, antioxidant, and other bioactive properties, holds significant potential for use in nutritional supplements and drug development. However, its extraction from medicinal plants is inefficient due to low yield and dependence on seasonality and geography. Herein, we use modular metabolic engineering to enhance ursolic acid production in by dividing the biosynthetic pathway into five modules.
View Article and Find Full Text PDFRejection of the concept of hemiurid genus Pulmovermis (Digenea: Hemiuridae) and other taxonomic propositions: new morphological and molecular data regarding Lecithochirium cyanovitellosum (Coil and Kuntz, 1960) Urabe and Sokolov, comb. nov. (formerly Pulmovermis cyanovitellosus).
Syst Parasitol
January 2025
A.N. Severtsov Institute of Ecology and Evolution RAS, Moscow, Russia.
Pulmovermis cyanovitellosus Coil and Kuntz, 1960 is a species of hemiurid trematode that localizes in the lung of sea snakes, an unusual trait for this group of parasites. Recent molecular phylogenetic studies based on 28S rRNA gene sequences have shown that this species is closely related to members of the genus Lecithochirium Lühe, 1901. This finding is unexpected given that Pulmovermis Coil and Kuntz, 1960 and Lecithochirium are currently classified in different subfamilies of Hemiuridae (Pulmoverminae Sandars, 1961 vs.
View Article and Find Full Text PDFPhylogeny of spp. (Decapoda, Pleocyemata) from Peru based on mitochondrial and nuclear data reveals a species complex comprising (Bouvier, 1895) and Holthuis, 1950.
Zookeys
January 2025
Peruvian University Cayetano Heredia, Av. Honorio Delgado 430, San Martín de Porres, Lima, Peru Peruvian University Cayetano Heredia Lima Peru.
Prawns of the genus represent a highly diverse group of high commercial value worldwide. Eight species have been reported from the Peruvian Pacific slope, but their phylogenetic relationships are still unknown. To investigate the systematics of species from Peru, morphological identification and molecular data from nucleotide sequences of three genes were used: cytochrome oxidase subunit I, 16S rRNA, and 28S rRNA.
View Article and Find Full Text PDFMorphological and molecular phylogeny of sp. (Digenea: Clinostomidae) metacercariae, using DNA barcode from a South American freshwater fish.
J Helminthol
January 2025
Universidade Federal de Alagoas (UFAL), Instituto de Ciências Biológicas e da Saúde, Departamento de Patologia e Parasitologia, Maceió, Alagoas, Brasil.
Here, we present a comprehensive morphological and molecular phylogenetic analysis of sp. (Digenea: Clinostomidae) metacercariae parasitizing two freshwater fish species from Southeast Brazil: (piranha) and (tambuatá). The morphological examination revealed distinct characteristics of metacercariae in each host.
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