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Purpose: To evaluate the effect of osilodrostat and hypercortisolism control on blood pressure (BP) and glycemic control in patients with Cushing's disease.
Methods: Pooled analysis of two Phase III osilodrostat studies (LINC 3 and LINC 4), both comprising a 48-week core phase and an optional open-label extension. Changes from baseline in systolic and diastolic BP (SBP and DBP), fasting plasma glucose (FPG), and glycated hemoglobin (HbA) were evaluated during osilodrostat treatment in patients with/without hypertension or diabetes at baseline.
Physiological responses of pacu (Piaractus mesopotamicus) to intermittent cold exposure: A comprehensive analysis of stress, immunity, antioxidant, and metabolic adaptations.
Fish Physiol Biochem
January 2025
São Paulo State University (UNESP), Aquaculture Center of UNESP, Jaboticabal, Sao Paulo, Brazil.
This study examined the energy-dependent physiological responses, including stress, innate immune, and antioxidant systems, as well as indicators of energy mobilization, in pacu (Piaractus mesopotamicus) exposed to intermittent cold, aiming to assess the correlations between these responses. The fish were acclimated to 28 °C, divided into two groups, a control group maintained at 28 °C, and another exposed to 16 °C for two 24 h periods with a 5-day interval between them. The fish were sampled at six time points: baseline (after acclimatization to 28 °C), 24 h after the 1st exposure to 16 °C, after 5 days of recovery at 28 °C, 24 h after the 2nd exposure to 16 °C, and after 24 and 48 h of recovery at 28 °C.
View Article and Find Full Text PDFBacteria-Produced Algicide for Field Control of Toxic Dinoflagellates Does Not Cause a Cortisol Stress Response in Two Estuarine Fish Species.
Mar Biotechnol (NY)
January 2025
College of Earth, Ocean and Environment, School of Marine Science and Policy, University of Delaware, Lewes, DE, 19958, USA.
Application of algicides produced by naturally occurring bacteria is considered an environmentally friendly approach to control harmful algal blooms. However, few studies assess the effects of bacterial algicides on non-target species, either independently or with other stressors. Here, we measured sub-lethal effects of dinoflagellate-specific algicide IRI-160AA on the estuarine fish Fundulus heteroclitus and Menidia menidia in laboratory experiments.
View Article and Find Full Text PDFProtective roles of herbal teas against the toxicity of Bisphenol A on morphometry of uterus and improving murine reproductive health (incomplete title and amended by the EIC).
Pak J Pharm Sci
January 2025
Department of Food Science and Nutrition, Alkhurmah University College, Taif University, Taif, Saudi Arabia.
The purpose of the current study was to investigate the potential ameliorating murine reproductive effects of herbal tea extracts against bisphenol A-induced (BPA) cytotoxicity. A comparative study was applied among red, green and blue teas in mice groups. Samples were coded as RTE, GTE and BTE groups, respectively.
View Article and Find Full Text PDFDevelopment of HRP-assisted rGO-FET biosensors for high-precision measurement of serological steroid hormones.
Anal Chim Acta
January 2025
Department of Medical Biotechnology, College of Life Science and Biotechnology, Dongguk University, Seoul, 04620, Republic of Korea. Electronic address:
Background: Sarcopenia, which is associated with many pathways and molecular mechanisms, not only deteriorates the quality of life in old age but is also linked to various diseases. The ratio between cortisol and dehydroepiandrosterone sulfate (DHEAS) was utilized as a candidate method to diagnose sarcopenia. The hormones can fluctuate in concentration throughout the day, so monitoring the ratio between the two hormones is necessary.
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