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Drug-induced hypoglycemia: a disproportionality analysis of the FAERS database.
Expert Opin Drug Saf
August 2024
Department of Pharmacy, Zhangjiagang TCM Hospital, Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, Jiangsu, China.
Article Synopsis
- * Researchers analyzed reports from 2004 to 2023, identifying 28,443 cases of hypoglycemia, with Metformin being the most reported drug associated with this risk.
- * The study highlighted that many top drugs linked to hypoglycemia were not labeled as such, indicating the need for better monitoring of these risks in medical settings.
Rate-dependent effects of monoamine releasers on intracranial self-stimulation in rats: implications for abuse liability assessment.
Behav Pharmacol
September 2013
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA.
'Rate dependency' in the discipline of behavioral pharmacology describes a phenomenon wherein the effect of a drug on the rate of a behavior varies systematically as a function of the baseline, predrug rate of that behavior. Historically, rate-dependency studies have compared drug effects on different baseline rates of behavior maintained either by different schedules of reinforcement or during sequential segments of a fixed-interval schedule. The current experiment generated different baseline rates of behavior by altering frequency of electrical stimulation in an intracranial self-stimulation assay.
View Article and Find Full Text PDFThe metabolism of anabolic-androgenic steroids in the greyhound.
Bioanalysis
April 2013
Australian Racing Forensic Laboratory. Currently with the Department of the President's Affairs, PO Box 17292, Al Ain, United Arab Emirates.
Background: Effective control of the use of anabolic-androgenic steroids (AASs) in animal sports is essential in order to ensure both animal welfare and integrity. In order to better police their use in Australian and New Zealand greyhound racing, thorough metabolic studies have been carried out on a range of registered human and veterinary AASs available in the region.
Results: Canine metabolic data are presented for the AASs boldenone, danazol, ethylestrenol, mesterolone, methandriol, nandrolone and norethandrolone.
In vitro study methodologies to investigate genetic aspects and effects of drugs used in attention-deficit hyperactivity disorder.
J Neural Transm (Vienna)
January 2013
Department of Child and Adolescent Psychiatry, University of Zurich, Neumuensterallee 9, 8032, Zurich, Switzerland.
Attention-deficit/hyperactivity disorder (ADHD) is one of the most common psychiatric disorders in children and adolescents, with up to 5 % affected worldwide. Twin and family studies on ADHD show its high familiality with heritability estimated around 70 %, but, to date, no specific polymorphism or gene was found to be specifically affected. Psychostimulants (amphetamine, methylphenidate) and non-psychostimulants (atomoxetine) are used successfully in ADHD therapy, but many of their mechanisms of action and their adverse effects are not yet fully understood.
View Article and Find Full Text PDFAccelerated sample treatment for screening of banned doping substances by GC-MS: ultrasonication versus microwave energy.
Anal Bioanal Chem
January 2011
REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnología, Universidade Nova de Lisboa, 2829-516, Monte de Caparica, Portugal.
A comparison between ultrasonication and microwave irradiation as tools to achieve a rapid sample treatment for the analysis of banned doping substances in human urine by means of gas chromatography-mass spectrometry (GC-MS) was performed. The following variables were studied and optimised: (i) time of treatment, (ii) temperature, (iii) microwave power and (iv) ultrasonic amplitude. The results were evaluated and compared with those achieved by the routine method used in the World Anti-Doping Agency (WADA) accredited Antidoping Laboratory of Rome.
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