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Exploring the Mutated Kinases for Chemoenzymatic Synthesis of -Modified Cytidine Monophosphates.
Molecules
August 2024
Department of Molecular Microbiology and Biotechnology, Institute of Biochemistry, Life Sciences Center, Vilnius University, Sauletekio Av. 7, LT-10257 Vilnius, Lithuania.
Nucleosides, nucleotides, and their analogues are an important class of molecules that are used as substrates in research of enzymes and nucleic acid, or as antiviral and antineoplastic agents. Nucleoside phosphorylation is usually achieved with chemical methods; however, enzymatic phosphorylation is a viable alternative. Here, we present a chemoenzymatic synthesis of modified cytidine monophosphates, where a chemical synthesis of novel -modified cytidines is followed by an enzymatic phosphorylation of the nucleosides by nucleoside kinases.
View Article and Find Full Text PDFMitochondrial deoxyguanosine kinase is required for female fertility in mice.
Acta Biochim Biophys Sin (Shanghai)
March 2024
Center for Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Diseases, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Life Sciences, Yunnan University, Kunming 650091, China.
Mitochondrial homeostasis plays a pivotal role in oocyte maturation and embryonic development. Deoxyguanosine kinase (DGUOK) is a nucleoside kinase that salvages purine nucleosides in mitochondria and is critical for mitochondrial DNA replication and homeostasis in non-proliferating cells. loss-of-function mutations and deletions lead to hepatocerebral mitochondrial DNA deletion syndrome.
View Article and Find Full Text PDFHigh level expression of nicotinamide nucleoside kinase from and its purification and immobilization by one-step method.
Front Bioeng Biotechnol
February 2023
Henan Provincial Key Laboratory of Funiu Mountain Insect Biology and Henan Provincal Engineering and Technology Center of Health Products for Livestock and Poultry, Nanyang Normal University, Nanyang, China.
Nicotinamide riboside kinase (NRK) plays an important role in the synthesis of β -nicotinamide nucleotide (NMN). NMN is a key intermediate of NAD synthesis, and it actually contribute to the well-being of our health. In this study, gene mining technology was used to clone nicotinamide nucleoside kinase gene fragments from , and the NRK1 was achieved a high level of soluble expression in E.
View Article and Find Full Text PDFThe Potential Protective Role of GS-441524, a Metabolite of the Prodrug Remdesivir, in Vaccine Breakthrough SARS-CoV-2 Infections.
Intensive Care Res
November 2022
Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Unity Health Toronto, Toronto, ON Canada.
Unlabelled: Cases of vaccine breakthrough, especially in variants of concern (VOCs) infections, are emerging in coronavirus disease (COVID-19). Due to mutations of structural proteins (SPs) (e.g.
View Article and Find Full Text PDFA plastid nucleoside kinase is involved in inosine salvage and control of purine nucleotide biosynthesis.
Plant Cell
January 2023
Department of Molecular Nutrition and Biochemistry of Plants, Leibniz Universität Hannover, Hannover 30419, Germany.
In nucleotide metabolism, nucleoside kinases recycle nucleosides into nucleotides-a process called nucleoside salvage. Nucleoside kinases for adenosine, uridine, and cytidine have been characterized from many organisms, but kinases for inosine and guanosine salvage are not yet known in eukaryotes and only a few such enzymes have been described from bacteria. Here we identified Arabidopsis thaliana PLASTID NUCLEOSIDE KINASE 1 (PNK1), an enzyme highly conserved in plants and green algae belonging to the Phosphofructokinase B family.
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