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Genetic Variability in the E6, E7, and L1 Genes of Human Papillomavirus Types 16 and 18 among Women in Saudi Arabia.
Viruses
December 2022
Department of Infection and Immunity, King Faisal Specialist Hospital and Research Center, Riyadh 11564, Saudi Arabia.
Cervical cancer is the eighth most frequent cancer in Saudi Arabia, and most cases are associated with human papillomavirus (HPV) types 16 and 18. HPV-induced carcinogenesis may be associated with the intra-type variant, genetic mutation, or the continuous expression of viral oncogenes E6 and E7. Infection efficiency and virus antigenicity may be affected by changes in the L1 gene.
View Article and Find Full Text PDFThe beginning and ending of a respiratory viral pandemic-lessons from the Spanish flu.
Microb Biotechnol
May 2022
Department of Biosystems, Laboratory of Gene Technology, KU Leuven, Leuven, Belgium.
The COVID-19 pandemic goes into its third year and the world population is longing for an end to the pandemic. Computer simulations of the future development of the pandemic have wide error margins and predictions on the evolution of new viral variants of SARS-CoV-2 are uncertain. It is thus tempting to look into the development of historical viral respiratory pandemics for insight into the dynamic of pandemics.
View Article and Find Full Text PDFGenetic Basis of Antigenic Variation of SAT3 Foot-And-Mouth Disease Viruses in Southern Africa.
Front Vet Sci
September 2020
Vaccine and Diagnostic Development Programme, Onderstepoort Veterinary Institute, Agricultural Research Council, Pretoria, South Africa.
Foot-and-mouth disease (FMD) continues to be a major burden for livestock owners in endemic countries and a continuous threat to FMD-free countries. The epidemiology and control of FMD in Africa is complicated by the presence of five clinically indistinguishable serotypes. Of these the Southern African Territories (SAT) type 3 has received limited attention, likely due to its restricted distribution and it being less frequently detected.
View Article and Find Full Text PDFEvidence of combined effect of amino acid substitutions within G-H and B-C loops of VP1 conferring serological heterogeneity in foot-and-mouth disease virus serotype A.
Transbound Emerg Dis
March 2021
Department of Microbiology, University of Dhaka, Dhaka, Bangladesh.
Article Synopsis
- FMDV serotype A displays significant genetic and antigenic diversity, leading to frequent vaccine failures and challenges in developing effective vaccines.
- The study focused on four FMDV serotype A isolates from Bangladesh, revealing that most strains demonstrated protective cross-reactivity with the vaccine strain, except for one isolate which had a notable mismatch.
- Detailed analysis of genetic variations showed that specific mutations in the VP1 G-H loop of the poorly matching isolate could be responsible for its distinct antigenic properties, influencing the design of future vaccines.
Development and validation of a simplified serotyping ELISA based on monoclonal antibodies for the diagnosis of foot-and-mouth disease virus serotypes O, A, C and Asia 1.
Transbound Emerg Dis
November 2020
Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia-Romagna, Brescia, Italy.
This study describes the development and validation of a simplified enzyme-linked immunosorbent assay (ELISA) for the detection and discrimination of foot-and-mouth disease virus (FMDV) serotypes O, A, C and Asia 1. The multiplex ELISA was designed using selected, type-specific monoclonal antibodies (MAbs) coated onto ELISA plates as catching antibodies and a unique pan-FMDV MAb (1F10) as detector conjugate. Capture MAbs with the broadest intratypic reactivity were selected for each of the four FMDV serotypes by screening large panels of candidate MAbs with a wide spectrum of representative FMDV isolates.
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