AI Article Synopsis
- Viruslike particles resembling the mouse leukemia agent were found in the thymus tissues of germ-free AK mice that had natural leukemia, using electron microscopy.
- Unique viruslike particles (type B) were also identified in the tissues of germ-free C3H mice with spontaneous mammary adenocarcinoma.
- The findings suggest that germ-free mice can still have viruses, indicating potential "vertical" transmission routes for leukemia and mammary tumor viruses through embryos or placentas.
Article Abstract
Kajima, Masahiro (University of Notre Dame, Notre Dame, Ind.), and Morris Pollard. Detection of viruslike particles in germ-free mice. J. Bacteriol. 90:1448-1454. 1965.-Viruslike particles similar in structure to the mouse leukemia agent were detected by electron microscopy in thymus tissues of germ-free AK mice which had developed spontaneous leukemia. In addition, unique viruslike particles (type B) were detected in tissues from spontaneous mammary adenocarcinoma of germ-free C3H mice. Leukemia virus-like particles were also observed in the thymuses of the control AK mice and of the C3H control mice as well as of those with mammary tumors. Germ-free mice are not virus-free. The routes of transmission of leukemia as well as of mammary tumor viruses may be "vertical," through the embryo or placenta.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC315834 | PMC |
| http://dx.doi.org/10.1128/jb.90.5.1448-1454.1965 | DOI Listing |
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