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Genotype-negative multiple endocrine neoplasia type 1 with prolactinoma, hyperparathyroidism, and subclinical Cushing's syndrome accompanied by hyperglycemia: a case report.
Front Endocrinol (Lausanne)
December 2024
Diabetes Center, Ohta Nishinouchi Hospital, Koriyama, Fukushima, Japan.
Background: Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant disorder, accompanied by multiple endocrine neoplasms of the parathyroid, pancreas, pituitary, and other neoplasms in the adrenal glands. However, in some cases, patients clinically diagnosed with MEN1 may be genotype-negative.
Case Presentation: A 56-year-old female was diagnosed with MEN1 based on a macroprolactinoma (19 mm in diameter), primary hyperparathyroidism, and a cortisol-producing adrenal adenoma, without a family history.
Poor maternal nutrition during gestation in sheep alters key hormonal systems involved in energy homeostasis and appetite in the offspring.
Domest Anim Endocrinol
December 2024
University of Connecticut, Department of Animal Science, 17 Manter Road Storrs, CT, 06269, USA. Electronic address:
Disturbances in maternal nutrient availability through increased or decreased abundance of specific or total nutrients during pre-natal development can have negative impacts on offspring growth. These changes are likely mediated, at least in part, by hormonal systems that control energy homeostasis and appetite. Regulation of insulin signaling is critical to ensuring appropriate glucose homeostasis.
View Article and Find Full Text PDFThe biological and psychological impact of the Coronavirus disease-19 pandemic on the characteristics of the menstrual cycle.
J Turk Ger Gynecol Assoc
December 2024
Department of Gynecology, Hospital Primavera, Aracaju, Brazil.
The Coronavirus disease-19 (COVID-19) pandemic was declared in March 2020 by the World Health Organization. The severe acute respiratory syndrome-coronavirus-2 virus enters host cells through angiotensin-converting enzyme 2 receptors and transmembrane serine protease type II that are expressed in pulmonary alveoli, as well as in hepatocytes, endothelium, ovaries, uterus, vagina, thyroid, and other tissues. In addition to viral injury, the COVID-19 pandemic, through protective measures such as social isolation and lockdown, has promoted a scenario of psychosocial stress, especially in women.
View Article and Find Full Text PDFMechanistic insights regarding neuropsychiatric and neuropathologic impacts of air pollution.
Crit Rev Toxicol
November 2024
Public Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA.
Air pollution is a significant environmental health risk for urban areas and developing countries. Air pollution may contribute to the incidence of cardiopulmonary and metabolic diseases. Evidence also points to the role of air pollution in worsening or developing neurological and neuropsychiatric conditions.
View Article and Find Full Text PDFAn emergency medicine review: Multiple myeloma and its complications.
Am J Emerg Med
November 2024
Department of Emergency Medicine, University of Ottawa, Ottawa, Canada. Electronic address:
Introduction: Multiple myeloma (MM) and its complications carry a high rate of morbidity and mortality.
Objective: This review evaluates MM and its complications, including presentation, diagnosis, and management in the emergency department (ED) based on current evidence.
Discussion: MM is the second most common hematologic cancer and associated with monoclonal plasma cell proliferation.
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