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Genotype-Phenotype Correlations in Corneal Dystrophies: Advances in Molecular Genetics and Therapeutic Insights.
Clin Exp Ophthalmol
March 2025
Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Science, The University of Auckland, Auckland, New Zealand.
Corneal dystrophies are a group of predominantly rare inherited disorders. They are by definition bilateral, relatively symmetrical, and without systemic involvement, affecting corneal transparency and/or refraction. Traditional classification of corneal dystrophies is based on slit-lamp appearance, affected corneal layer and histological features.
View Article and Find Full Text PDFAssessment of Risk of Malignancy by Application of the Proposed IAC-IARC-WHO Cytopathology System for Classification and Reporting of Soft Tissue Lesions: An Experience From Tertiary Care Center From India.
Diagn Cytopathol
March 2025
Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Bhubaneswar, India.
Introduction: Soft tissue lesions encompass a diverse category of diseases from benign to malignant, and their morphology might overlap; therefore, accurate categorization is needed to approach the reporting of soft tissue cytology. The cytology of these lesions is helpful in detecting the features of malignancy, which helps in guiding further management. In this study, we applied the proposed IAC-IARC-WHO cytopathology system to assess the risk of malignancy (ROM) and diagnostic accuracy (DA) for the determination of its clinical and diagnostic utility.
View Article and Find Full Text PDFInorganic Nanomaterials Meet the Immune System: An Intricate Balance.
Adv Healthc Mater
March 2025
Department of Pharmacy, School of Medical and Pharmaceutical Sciences, University of Genoa, Viale Cembrano 4, Genoa, 16148, Italy.
The immune system provides defense against foreign agents that are considered harmful for the organism. Inorganic nanomaterials can be recognized by the immune system as antigens, inducing an immune reaction dependent on the patient's immunological anamnesis and from several factors including size, shape, and the chemical nature of the nanoparticles. Furthermore, nanomaterials-driven immunomodulation might be exploited for therapeutic purposes, opening new horizons in oncology and beyond.
View Article and Find Full Text PDFMXenes and MXene-based composites for biomedical applications.
J Mater Chem B
March 2025
Clinical Translational Research Center of Aggregation-Induced Emission, School of Medicine, The Second Affiliated Hospital, School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Guangdong 518172, P. R. China.
MXenes, a novel class of two-dimensional materials, have recently emerged as promising candidates for biomedical applications due to their specific structural features and exceptional physicochemical and biological properties. These materials, characterized by unique structural features and superior conductivity, have applications in tissue engineering, cancer detection and therapy, sensing, imaging, drug delivery, wound treatment, antimicrobial therapy, and medical implantation. Additionally, MXene-based composites, incorporating polymers, metals, carbon nanomaterials, and metal oxides, offer enhanced electroactive and mechanical properties, making them highly suitable for engineering electroactive organs such as the heart, skeletal muscle, and nerves.
View Article and Find Full Text PDFPrurigo pigmentosa following laparoscopic sleeve gastrectomy: a case report.
J Surg Case Rep
March 2025
Department of General Surgery, Prince Sultan Military Medical City, Riyadh Makkah Al Mukarramah Road, As Sulimaniyah, Riyadh, 12233, Saudi Arabia.
Prurigo pigmentosa (PP) is a rare dermatological condition with an unclear, often idiopathic etiology, but recent evidence points to a potential link between the disease and metabolic changes, particularly those associated with ketosis. It typically presents as a pruritic, erythematous rash, mainly affecting the trunk and neck, and often features hyperpigmented macules and plaques. The onset of PP has been associated with various factors, including fasting, dieting, and certain metabolic disorders.
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