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Genome-wide analysis of genetic diversity in a germplasm collection including wild relatives and interspecific clones of garden asparagus.
Front Plant Sci
July 2023
Council for Agricultural Research and Economics - Research Centre for Genomics and Bioinformatics (CREA-GB), Montanaso Lombardo, LO, Italy.
The genus includes approximately 240 species, the most important of which is garden asparagus ( L.), as this is a vegetable crop cultivated worldwide for its edible spear. Along with garden asparagus, other species are also cultivated (e.
View Article and Find Full Text PDFOral and anal microbiome from HIV-exposed individuals: role of host-associated factors in taxa composition and metabolic pathways.
NPJ Biofilms Microbiomes
July 2023
Centro de Investigaciones Inmunológicas Básicas y Aplicadas (CINIBA), Facultad de Ciencias Médicas, Universidad Nacional de La Plata, La Plata, Argentina.
Evidence indicates that the microbiome plays a significant role in HIV immunopathogenesis and associated complications. This study aimed to characterize the oral and anal microbiome of Men who have Sex with Men (MSM) and Transgender Women (TGW), with and without HIV. One hundred and thirty oral and anal DNA-derived samples were obtained from 78 participants and subjected to shotgun metagenomics sequencing for further microbiome analysis.
View Article and Find Full Text PDFAntiretroviral Penetration and Drug Transporter Concentrations in the Spleens of Three Preclinical Animal Models and Humans.
Antimicrob Agents Chemother
September 2020
University of North Carolina Eshelman School of Pharmacy, Chapel Hill, North Carolina, USA
Adequate antiretroviral (ARV) concentrations in lymphoid tissues are critical for optimal antiretroviral therapy (ART). While the spleen contains 25% of the body's lymphocytes, there are minimal data on ARV penetration in this organ. This study quantified total and protein-unbound splenic ARV concentrations and determined whether drug transporters, sex, or infection status were modifiers of these concentrations in animal models and humans.
View Article and Find Full Text PDFInteractions of Tofacitinib and Dexamethasone on Lymphocyte Proliferation.
Pharm Res
May 2020
Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, 404 Pharmacy Building, Buffalo, NY, 14214-8033, USA.
Purposes: Lymphocyte proliferation is a major factor determining the magnitude of the immune response. Both dexamethasone (DEX) and tofacitinib (TOF) exert marked immunosuppressive effects and are mainstay drugs in the treatment of rheumatoid arthritis (RA). This study was aimed to explore the single and combined anti-proliferative action of DEX and TOF on lymphocytes and their sex differences.
View Article and Find Full Text PDFPopulation- and Species-Based Variation of Webworm-Parasitoid Interactions in Hogweeds (Heracelum spp.) in the Netherlands.
Environ Entomol
August 2020
Laboratory of Entomology, Wageningen University, Wageningen, The Netherlands.
In three Dutch populations of the native small hogweed (Heracleum sphondylium L. [Apiales: Apiaceae]), and one of the invasive giant hogweed (H. mantegazzianum Sommeier & Levier [Apiales: Apiaceae]), interactions between a specialist herbivore, the parsnip webworm (Depressaria radiella), and its associated parasitoids were compared during a single growing season.
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