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The Severity of Allergic Reactions in a Real-World Environment Is Independent of the Eliciting Amounts of Foods.
Allergy
January 2025
Pediatric Allergy Unit, Department of Woman, Child and Adolescent, University Hospitals of Geneva (HUG), Geneva, Switzerland.
Introduction: Patients with food allergies need personalized information on their risk of reaction in "real-life" situations. This multicentric study aimed to investigate the link during accidental reactions between the nature and amount of food allergens consumed in "real-life situation" and the severity of the symptoms.
Methods: Patients were prospectively recruited from December 1, 2020, to December 31, 2021, at the emergency departments in the Geneva University Hospitals and local pediatric emergency facilities, through an allergy outpatient clinic, at school and daycare facilities and trough their primary care physicians.
A high titer antibody response against P22 protein immunocomplex is not correlated with protection in naturally tuberculosis-infected goats.
Vet Q
December 2024
Department of Animal Health, Faculty of Veterinary Medicine, Complutense University of Madrid, Madrid, Spain.
Caprine livestock are significant reservoirs of the complex (MTBC), contributing to tuberculosis (TB) transmission among animals and humans. The P22 protein immunocomplex (P22PI), derived from bovine tuberculin, shows immunostimulating capacity and is used for TB diagnosis. This study assessed the immunogenicity and protective efficacy of P22PI in two groups of goats: 24 naïve goats (12 immunised, 12 controls) from a TB-free herd, and 24 infected goats (12 immunised, 12 controls), referred to as pre-infected animals, from a -infected herd.
View Article and Find Full Text PDFBiofilm formation dynamics in long-distance water conveyance pipelines: Impacts of nutrient levels and metal stress.
Water Res
January 2025
State Key Laboratory of Pollution Control and Resource Reuse, School of Environment, Nanjing University, Nanjing 210023, China. Electronic address:
Biofilm formation in long-distance water conveyance pipelines poses significant risks to water quality, particularly under varying nutrient levels and heavy metal stress. However, the impacts of pipeline material on biofilm formation dynamics under different raw water conditions remain elusive. This study investigated the effects of nutrient availability and Fe-Mn stress on biofilm development, structural stability, bacterial community composition, and the occurrence of viable but non-culturable (VBNC) bacteria.
View Article and Find Full Text PDFImmunosensors are crucial for various applications, with capture efficiency and detection time as key performance parameters. Sessile droplets on functionalized substrates have demonstrated potential as micro-reactors for antibody-antigen binding, reducing detection time and analyte volume due to the presence of convective currents. Tuning the surface charges by adjusting buffer pH can modulate antigen capture efficiency.
View Article and Find Full Text PDFPlatinum-perovskite nanocomposite-based Exosensor for specific detection of prostate cancer in clinical settings.
Mikrochim Acta
September 2024
Department of Physics, Faculty of Science, University of Sakarya, Sakarya, Turkey.
Exosomes, extracellular vesicles (EVs) with an average size of 50-150 nm, transfer various biomolecules and exchange signaling molecules between cells in a paracrine manner. Molecular investigations have revealed that EVs can reflect real-time metabolic changes in normal- and cancer-origin cells and thus harbor valid diagnostic biomarkers. Despite these advantages, the detection of low concentrations of cancer cell EVs in biological fluids is still a great challenge.
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