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Investigation into the PSD characteristics of internally unstable soils susceptible to suffosion.
Sci Rep
January 2025
College of Water Conservancy and Hydropower Engineering, Hohai University, Nanjing, 210098, China.
Internal instability of embankment soils under seepage can occur in two distinct ways: suffusion and suffosion. Suffusion involves the removal of fine particles from the matrix without causing significant disturbance to the soil skeleton, while suffosion is characterized by the movement of fine particles accompanied by skeleton collapse or deformation. In terms of dam safety, suffosion poses a greater threat than suffusion.
View Article and Find Full Text PDFObjective: To explore how women who used substances during the perinatal period perceived the care they received from interprofessional perinatal care providers.
Design: Appreciative inquiry.
Setting: Interprofessional perinatal care clinic in a large urban tertiary care hospital in Canada.
New potential susceptibility factors contributing to tomato bacterial spot disease.
J Proteomics
January 2025
Embrapa Recursos Genéticos e Biotecnologia, PBI, Av. W/5 Norte Final CEP 70770917, Brazil. Electronic address:
The label-free shotgun proteomics analysis carried out in this study aimed to understand the molecular mechanisms that contribute towards tomato susceptibility to Xanthomonas euvesicatoria pv. perforans (Xep). To achieve this, comparative proteomics was performed on susceptible inoculated plants with the bacterium and the control group (saline solution) at 24 and 48 h after inoculation (hai).
View Article and Find Full Text PDFMarR family regulator LcbR2 activates lincomycin biosynthesis in multiple ways.
Int J Biol Macromol
January 2025
Department of Applied Biology, School of Biotechnology, East China University of Science and Technology, Shanghai 200237, China.
Lincomycin, produced by the actinomycete Streptomyces lincolnensis, is highly effective against Gram-positive bacteria and protozoans, making it widely used in clinical settings. This study identified LcbR2, a MarR family transcriptional regulator, as an activator of lincomycin biosynthesis. Knocking out the lcbR2 gene reduced lincomycin production by 63.
View Article and Find Full Text PDFRecombinant Antibodies Inhibit Enzymatic Activity of the E3 Ubiquitin Ligase CHIP via Multiple Mechanisms.
J Biol Chem
January 2025
Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address:
Carboxyl-terminus of Hsp70-Interacting Protein (CHIP) is an E3 ubiquitin ligase that marks misfolded substrates for degradation. Hyper-activation of CHIP has been implicated in multiple diseases, including cystic fibrosis and cancer, suggesting that it may be a potential drug target. However, there are few tools available for exploring this possibility.
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