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Angiosome-Guided Perfusion Decellularization of Fasciocutaneous Flaps.
J Reconstr Microsurg
September 2024
Division of Plastic Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Background: Tissue engineering based on whole-organ perfusion decellularization has successfully generated small-animal organs, including the heart and limbs. Herein, we aimed to use angiosome-guided perfusion decellularization to develop an acellular fasciocutaneous flap matrix with an intact vascular network.
Methods: Abdominal flaps of rats were harvested, and the vascular pedicle (iliac artery and vein) was dissected and injected with methylene blue to identify the angiosome region and determine the flap dimension for harvesting.
Transmenopausal changes in cortical bone quality.
Bone
October 2024
Osteoporosis Research Center, Creighton University, Omaha, NE, USA.
Bone's resistance to fracture depends on its amount and quality, the latter including its structural and material/compositional properties. Bone material properties are dependent on bone turnover rates, which are significantly elevated immediately following menopause. Previously published data reported that following menopause, the amount of organic matrix synthesized at actively forming surfaces is significantly decreased, while glycosaminoglycan content was also modulated at resorbing surfaces, in the cancellous compartment.
View Article and Find Full Text PDFBiomechanical, biochemical, and histological characterization of sacroiliac joint cartilage in the Yucatan minipig.
J Mech Behav Biomed Mater
September 2024
Department of Biomedical Engineering, 3131 Engineering Hall, University of California, Irvine, CA, 92617, USA. Electronic address:
Although the sacroiliac (SI) joint can be a source of lower back and buttock pain, no comprehensive characterization studies on SI cartilage have been conducted. Using the minipig as a large animal model, this study conducted the first biomechanical, biochemical, and histological characterization of SI joint cartilage. Because previous literature has reported that sacral cartilage and iliac cartilage within the SI joint are histologically distinct, concomitantly it was expected that functional properties of the sacral cartilage would differ from those of the iliac cartilage.
View Article and Find Full Text PDFEffectiveness and Safety of Early Versus Routine Switching from Low-Molecular-Weight Heparin to Maintenance Therapy of Rivaroxaban for Acute Iliofemoral Vein Thrombosis: A Retrospective Cohort Study.
Ann Vasc Surg
September 2024
Department of Pharmacy, Tianjin Hospital, Tianjin, China. Electronic address:
Article Synopsis
- The study evaluates the effectiveness and safety of switching from low-molecular-weight heparin (LMWH) to rivaroxaban for treating acute iliofemoral deep vein thrombosis (DVT) after one week of initial treatment.
- Patients who switched to rivaroxaban early (within 7 days) had a significantly shorter hospital stay compared to those who switched later (more than 7 days), but there were no major differences in complications or mortality between the two groups.
- The findings suggest that early switching to rivaroxaban is both effective and safe for managing acute iliofemoral DVT.
Mechanical, structural, and morphological differences in the iliac arteries.
J Mech Behav Biomed Mater
July 2024
Department of Biomechanics, University of Nebraska Omaha, Omaha, NE, USA. Electronic address:
Iliac arteries play a crucial role in peripheral blood circulation. They are susceptible to various diseases, including aneurysms and atherosclerosis. Structure, material properties, and biomechanical forces acting on different regions of the iliac vasculature may contribute to the localization and progression of these pathologies.
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