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Behenic acid protects the testosterone cycle and prevents the sperm apoptosis and protein loss in phthalate exposure by inhibiting oxidative stress and stimulating ATPase activity.
Toxicol Rep
December 2024
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, P.O. Box.11562, Cairo, Egypt.
Background: Plastic products use phthalate to enhance their flexibility, transparency, and stability, while behenic acid is a carboxylic acid with antioxidant activity.
Objectives: This study evaluates whether behenic acid can protect the testosterone cycle and prevent the sperm apoptosis and protein loss in phthalate-treated male rats.
Methods: There were 36 male albino rats in all, divided into six equal sets of six rats each: control, behenic acid (13 g/kg), behenic acid (26 g/kg), diethyl phthalate (10 mg/kg), behenic acid (13 g/kg) + diethyl phthalate (10 mg/kg), and behenic acid (26 g/kg) + diethyl phthalate (10 mg/kg)-treated groups.
Identification of Lipomatous Metaplasia in a Cortisol-secreting Adrenocortical Adenoma Treated With Mifepristone.
JCEM Case Rep
October 2024
Palmetto Endocrinology, Palmetto Primary & Specialty Care Physicians, Summerville, SC 29483, USA.
Article Synopsis
- * A case presented involved a patient with hypertension, hyperlipidemia, and type II diabetes, whose adrenal adenoma was discovered due to progressive hirsutism and was found to cause Cushing syndrome.
- * After surgical removal of the tumor, the patient's symptoms improved significantly, allowing a reduction in medications, and histopathological analysis revealed the adrenal adenoma featured rare lipomatous metaplasia and uncertain malignant potential.
Extended Chemical and Microbial Stability of Various Hormones in Phytobase and HRT Heavy Cream Bases.
Int J Pharm Compd
August 2024
Compounding Support Services, Fagron Academy, St. Paul, Minnesota, USA.
Article Synopsis
- The 2023 updates to USP chapter <800> and major revisions to USP <795> have made previous studies for extended beyond use dates (BUD) inadequate, prompting a need for new evidence in compounding.
- Researchers conducted stability indicating testing and antimicrobial effectiveness testing (AET) on 12 combinations of topical and transdermal hormone preparations using two cream vehicles, Phytobase™ and HRT Heavy™, resulting in a total of 24 tested formulas.
- The study evaluates the appropriateness of Phytobase™ and HRT Heavy™ for compounded hormone therapy (CHT) and examines their compatibility with various hormones like estriol, estradiol, testosterone, progesterone, and dehydroepiandroster
Pre-analytical stability and physiological fluctuations affect plasma steroid hormone outcomes: A real-world study.
J Steroid Biochem Mol Biol
November 2024
Department of Laboratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China. Electronic address:
Since steroids are crucial for diagnosing endocrine disorders, the lack of research on factors that affect hormone levels makes interpreting the results difficult. Our study aims to assess the stability of the pre-analytical procedure and the impact of hormonal physiological fluctuations using real-world data. The datasets were created using 12,418 records from individuals whose steroid hormone measurements were taken in our laboratory between September 2019 and March 2024.
View Article and Find Full Text PDFAssessment of the diagnostic efficacy of radiological and functional evaluation of primary adrenal mass and its' surgical outcomes.
Urologia
November 2024
Department of Urology and Renal Transplant, S.C.B. Medical College & Hospital, Cuttack, Odisha, India.
Introduction: Objective of this study was to assess the diagnostic efficacy of the most commonly used radiological evaluation in form of contrast enhanced computed tomography of abdomen with adrenal protocol, basic functional evaluation and surgical outcomes of primary adrenal masses.
Material And Methods: We have retrospectively analysed the institutional records of 108, patients admitted from August 2017 to September 2023, who had underwent surgical intervention for their adrenal mass after thorough evaluation and stabilization.
Results: Flank pain was the most common symptoms in 44 (40.
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