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Vδ2 T-cells response in people with Mpox infection: a three-month longitudinal assessment.
Emerg Microbes Infect
January 2025
HIV/AIDS Unit, National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, Rome, Italy.
The first evidence that Orthopoxvirus induced the expansion and the recall of effector innate Vδ2T-cells was described in a macaque model. Although, an engagement of αβ T-cells specific response in patients infected with human monkeypox (Mpox) was demonstrated, little is known about the role of γδ T-cells during Mpox infection. IFN-γ-producing γδ T-cells in the resistance to poxviruses may a key role in inducing a protective type 1 memory immunity.
View Article and Find Full Text PDFMicronutrient status and risk of Mycobacterium tuberculosis infection in Indonesian tuberculosis case contacts.
Trans R Soc Trop Med Hyg
January 2025
Research Center for Care and Control of Infectious Disease, Universitas Padjadjaran, Bandung 45363, Indonesia.
Background: Certain micronutrient levels have been associated with the risk of developing TB disease. We explored the possible association of selected at-risk micronutrient levels with the development of Mycobacterium tuberculosis (M.tb) infection.
View Article and Find Full Text PDFPersonalized Nanovaccine Based on STING-Activating Nanocarrier for Robust Cancer Immunotherapy.
ACS Nano
January 2025
Medical Research Center, The First Affiliated Hospital of Zhengzhou University, The Center of Infection and Immunity, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China.
Tumor-specific T cells play a vital role in potent antitumor immunity. However, their efficacy is severely affected by the spatiotemporal orchestration of antigen-presentation as well as the innate immune response in dendritic cells (DCs). Herein, we develop a minimalist nanovaccine that exploits a dual immunofunctional polymeric nanoplatform (DIPNP) to encapsulate ovalbumin (OVA) via electrostatic interaction when the nanocarrier serves as both STING agonist and immune adjuvant in DCs.
View Article and Find Full Text PDFSeroprevalence of and Associated Risk Factors for Bovine Viral Diarrhea in Dairy Cattle in and Around Nekemte Town, East Wallaga, Oromiya Regional State, Ethiopia.
Biomed Res Int
January 2025
College of Agriculture and Veterinary Medicine, Jimma University, Jimma, Ethiopia.
Bovine viral diarrhea virus (BVDV) is an important pathogen affecting dairy cattle all over the world by causing significant economic losses due to reproductive and respiratory problems, immunosuppressive effects, increased risk of morbidity, and calf mortality. A cross-sectional study was conducted from February 2021 to August 2021 to determine the seroprevalence of bovine viral diarrhea (BVD) and identify risk factors associated with its occurrence in and around Nekemte Town of Ethiopia. Blood samples were collected from 305 dairy cattle of 41 herds by using cluster-sampling method.
View Article and Find Full Text PDFProtein nanoparticles as potent delivery vehicles for polycytosine RNA-binding protein one.
World J Diabetes
January 2025
State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy, Jinan University, Guangzhou 511436, Guangdong Province, China.
Ma recently reported in the that ferroptosis occurs in osteoblasts under high glucose conditions, reflecting diabetes pathology. This condition could be protected by the upregulation of the gene encoding polycytosine RNA-binding protein 1 (PCBP1). Additionally, Ma used a lentivirus infection system to express PCBP1.
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