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Results of Response-Guided Therapy with Pegylated Interferon Alpha 2a in Chronic Hepatitis B and D.
Trop Med Infect Dis
March 2024
Infectious Diseases Department, Universitatea de Medicina si Farmacie "Carol Davila", 050474 Bucuresti, Romania.
Article Synopsis
- Pegylated interferon alpha 2a is still used to treat chronic hepatitis D, showing a virologic response of 17-47% but with over 50% of patients experiencing relapses.
- In a study of 76 patients under a Romanian protocol, treatment typically lasted 48 to 96 weeks, with specific criteria for stopping and restarting based on viral load changes.
- Out of the monitored patients, 35.5% showed significant viral load reduction after 6 months, with a subset achieving undetectable levels for at least 24 weeks post-treatment, while moderate adverse reactions were common.
A regular screening for hepatitis delta virus among chronic hepatitis B carriers improves the diagnostic of this infection and of subsequent cirrhosis development.
United European Gastroenterol J
May 2024
Department of Gastroenterology and Hepatology, CHU Saint-Pierre, Brussels, Belgium.
Background And Objective: The prevalence of Hepatitis Delta Virus (HDV) is underestimated and the assessment of fibrosis is recommended for this infection. We tested the diagnostic impact of an annual screening for HDV serology in Hepatitis B Surface Antigen (HBs Ag) chronic carriers and followed the progression of fibrosis in these patients.
Methods: Between January 2014 and October 2021, we annually tested all chronic HBs Ag-positive patients for HDV antibody (HDV Ab).
Assessment of Long-Term Outcomes in Hbs Ag-Negative Renal Transplant Recipients Transplanted from Hbs Ag-Positive Donors.
Ann Transplant
July 2015
Department of Internal Medicine, Division of Nephrology, Akdeniz University Medical School, Antalya, Turkey.
Background: The aim of this study was to evaluate the long-term outcomes of renal transplantation from Hbs Ag-positive donors to Hbs Ag-negative recipients.
Material And Methods: A total of 78 patients who underwent renal transplantation in our clinic between January 2006 and May 2014 were included in the study. Patients were divided into 2 groups: Group 1: Donor Hbs Ag (+) (n=26, Hbs Ab (-), Hbe Ag (-), Hbe Ab (+), Hbc Ig total (+) and HBV DNA (+), male/female (M/F): 16 (61.
Prevalence of hepatitis B virus seromarkers in young adults vaccinated at birth; impact on the epidemiology of hepatitis B infection in iran.
Hepat Mon
May 2014
Department of Statistics, Mazandaran University of Medical Sciences, Sari, IR Iran.
Background: The epidemiological impact and the duration of protection provided by infant hepatitis B (HB) vaccination are unknown.
Objectives: This study was designed to determine the hepatitis B virus (HBV) infection seromarkers in young adults who have been vaccinated against HBV as the first group of Iranian neonates during 1993 and 1994.
Patients And Methods: We recruited 510 young adults with a history of complete HB vaccination at birth.
Aims: The purpose of this study was to evaluate the renal side-effects of adefovir therapy in kidney-transplant (KT) recipients with chronic hepatitis B virus (HBV) infection, who have become resistant to lamivudine therapy.
Patients And Methods: 11 kidney-transplant (KT) patients (10 men, 1 woman, median age 54 (46 - 67) years) had lamivudine-resistant chronic HBV infection. With respect to HBV markers, all were HBs Ag-positive, 8 were HBe Ag-negative/HBe antibody- (Ab) positive, i.
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