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Leukemia cutis as an initial presentation in a case of mixed phenotype acute leukemia: a double jeopardy.
Int J Clin Exp Pathol
August 2024
Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research Puducherry, India.
Article Synopsis
- Leukemia cutis (LC) occurs when leukemic cells infiltrate the skin, causing various types of skin lesions, including nodules and rashes.
- LC can appear before or after the diagnosis of leukemia, and its presence often indicates a more serious prognosis.
- The report highlights a case of Mixed phenotype Acute leukemia (MPAL) presenting as LC, emphasizing the need for timely identification and treatment with chemotherapy for better patient outcomes.
Isolated Cutaneous Chronic Lymphocytic Leukemia: A Case Report.
J Investig Med High Impact Case Rep
May 2024
Farhat Hached University Hospital, Sousse, Tunisia.
Article Synopsis
- Skin lesions occur in 4% to 20% of patients with chronic lymphocytic leukemia (CLL) and are less common than in T-cell leukemia.
- These lesions often present as leukemic cutis or secondary conditions like urticaria, itching, and cutaneous vasculitis.
- The case discussed involves a patient whose skin lesions led to the late diagnosis of isolated cutaneous CLL, highlighting the need for improved awareness and prompt diagnosis to enhance treatment outcomes.
Sezary Syndrome: A Case Report and Review of Current Therapeutics.
Cureus
April 2024
Hematology/Oncology, Infirmary Health System, Mobile, USA.
Sezary syndrome (SS) is a rare but aggressive type of cutaneous T-cell lymphoma (CTCL). Patients with SS have characteristic skin lesions (erythroderma) and a leukemic phase. The rash associated with CTCLs can often mimic common benign skin conditions such as psoriasis, atopic dermatitis, etc.
View Article and Find Full Text PDFMycosis fungoides and Sézary syndrome: clinical presentation, diagnosis, staging, and therapeutic management.
Front Oncol
April 2023
Division of Clinical Dermatology, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, Brazil.
Mycosis fungoides (MF) and Sézary syndrome (SS) are cutaneous T-cell lymphomas. MF is the most common cutaneous lymphoma, and it is classified into classic Alibert-Bazin MF, folliculotropic MF, pagetoid reticulosis, and granulomatous slack skin, each with characteristic clinical presentation, histopathological findings, and distinct clinical behaviors. SS is an aggressive leukemic variant of cutaneous lymphoma, and it is characterized by erythroderma, lymphadenopathy, and peripheral blood involvement by malignant cells.
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