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Cysteine-Directed Isobaric Labeling Combined with GeLC-FAIMS-MS for Quantitative Top-Down Proteomics.
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Systematic Proteome Research & Bioanalytics, Institute for Experimental Medicine, Christian-Albrechts-Universität zu Kiel, 24105 Kiel, Germany.
The quantification of proteoforms, i.e., all molecular forms in which proteins can be present, by top-down proteomics provides essential insights into biological processes at the molecular level.
View Article and Find Full Text PDFA solvent-free thermal desorption-gas chromatography-tandem mass spectrometry method (TD-GC-MS/MS) for the determination of polycyclic aromatic hydrocarbons in gas phase airborne samples.
J Chromatogr A
January 2025
Environmental Health Laboratory Branch, Center for Laboratory Sciences, California Department of Public Health, Richmond, CA 94804, USA.
A solvent-free, thermal extraction method for analysis of polycyclic aromatic hydrocarbons (PAHs) in gas phase airborne samples was developed. A fully automated thermal desorber (TD) coupled with highly selective and sensitive gas chromatography-tandem mass spectrometry (GC-MS/MS) was used to determine the concentration of trace level PAHs. Air sampling was conducted to tune the sampling and analytical conditions.
View Article and Find Full Text PDFHydrogen Sulfide (HS) Generated in the Colon Induces Neuropathic Pain by Activating Spinal NMDA Receptors in a Rodent Model of Chronic Constriction Injury.
Neurochem Res
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Department of Orthopaedics, Tianjin Hospital, Tianjin University, Tianjin, China.
Neuropathic pain (NP) imposes a significant burden on individuals, manifesting as nociceptive anaphylaxis, hypersensitivity, and spontaneous pain. Previous studies have shown that traumatic stress in the nervous system can lead to excessive production of hydrogen sulfide (HS) in the gut. As a toxic gas, it can damage the nervous system through the gut-brain axis.
View Article and Find Full Text PDFChemical Profiling, Antioxidant, and Antiproliferative Activities of Algerian Cistus creticus L. Leaf Extracts: Evidence from In vitro and In Silico Studies.
Curr Top Med Chem
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Medicinal Chemistry Department, Theodor Bilharz Research Institute Kornaish El Nile, Warrak El-Hadar, Imbaba (P.O. 30), Giza 12411, Egypt.
Background: Research into oxidative stress, cancer, and natural products revealed promising avenues for therapeutic intervention. Natural products are considered potent pharmaceuticals in combating oxidative stress and its relationship with cancer.
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Empowering climate resilience: A people-centered exploration of Thailand's greenhouse gas emissions trading and sustainable environmental development through climate risk management in community forests.
Heliyon
January 2025
College of Politics and Governance, Mahasarakham University, Kantharawichai District, Mahasarakham, 44150, Thailand.
The imperative of addressing climate change has accentuated the pivotal role of reducing greenhouse gas emissions and harnessing the potential of community forests. This study meticulously explores the governance structures and mechanisms underpinning greenhouse gas emissions trading within community forests, aimed at curbing carbon emissions, and enhancing adaptive capacities in Thailand. With a central focus on cultivating enduring climate resilience, this research delves into the interplay of community perspectives with greenhouse gas emissions trading mechanisms, while also dissecting the genesis of sustainable strategies in the Thai context.
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