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d-Amphetamine and Feeding States Cohesively Affect Locomotion and Motor Neuron Response in Zebrafish Larvae.
Brain Behav
December 2024
Department of Mechanical and Industrial Engineering, The University of Illinois at Chicago, Chicago, Illinois, USA.
Purpose: Amphetamine (AMPH) increases locomotor activities in animals, and the locomotor response to AMPH is further modulated by caloric deficits such as food deprivation and restriction. The increment in locomotor activity regulated by AMPH-caloric deficit concomitance can be further modulated by varying feeding schedules (e.g.
View Article and Find Full Text PDFAdverse effects of glyphosate-based herbicide on hatching rate, morphological alterations, and acetylcholinesterase (AChE) expression in golden apple snail eggs.
Aquat Toxicol
December 2024
Department of Fisheries, Faculty of Agriculture and Technology, Rajamangala University of Technology Isan Surin Campus, Surin 32000 Thailand. Electronic address:
Article Synopsis
- This research examined how glyphosate herbicide affects golden apple snail eggs, specifically looking at hatching rates, physical changes, and the expression of the enzyme acetylcholinesterase (AChE) as an exposure biomarker.
- The study found that higher concentrations and longer exposure to glyphosate led to decreased hatching success and morphological defects in the eggs, as revealed through various analytical methods such as optical coherence tomography.
- Key bioactive components in the eggs were characterized, showing that glyphosate exposure reduced these protective substances, which may have consequences for snail populations and the health of aquatic ecosystems.
Amphetamine-Dextroamphetamine-Induced Cardiomyopathy: A Case Report on Heart Failure in a Young Addict.
Cureus
October 2024
Cardiology, Althager General Hospital, Jeddah, SAU.
Article Synopsis
- * A case study of a 32-year-old man revealed his heart failure with reduced ejection fraction was associated with amphetamine use, raising concerns about drug-induced deterioration of existing heart conditions.
- * Effective management of patients with ADHD and heart issues requires careful monitoring by a multidisciplinary team and a complete pharmaceutical regimen to prevent further cardiac problems.
Effect of bariatric surgery on the pharmacokinetics of drugs used for attention-deficit hyperactivity disorder-A case series.
Basic Clin Pharmacol Toxicol
January 2025
Department of Clinical Pharmacology, Clinic of Laboratory Medicine, St. Olav University Hospital, Trondheim, Norway.
Background: Changes in gastrointestinal physiology following bariatric surgery may affect the pharmacokinetics of drugs. Data on the impact of bariatric surgery on drugs used for attention-deficit/hyperactivity disorder (ADHD) are limited.
Methods: In patients treated with ADHD medication and undergoing bariatric surgery, serial drug concentrations were measured for 24 h preoperatively and one, six and 12 months postoperatively.
Effects of SRI-32743, a Novel Quinazoline Structure-Based Compound, on HIV-1 Tat and Cocaine Interaction with Norepinephrine Transporter.
Int J Mol Sci
July 2024
Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, 715 Sumter Street, Columbia, SC 29208, USA.
Prolonged exposure to HIV-1 transactivator of transcription (Tat) protein dysregulates monoamine transmission, a physiological change implicated as a key factor in promoting neurocognitive disorders among people living with HIV. We have demonstrated that in vivo expression of Tat in Tat transgenic mice decreases dopamine uptake through both dopamine transporter (DAT) and norepinephrine transporter (NET) in the prefrontal cortex. Further, our novel allosteric inhibitor of monoamine transporters, SRI-32743, has been shown to attenuate Tat-inhibited dopamine transport through DAT and alleviates Tat-potentiated cognitive impairments.
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