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The Effectiveness of E-Learning Anticipatory Guidance on Early Childhood Caries among the Mothers of Children Aged 9-24 Months during the Pandemic: A Nonrandomized Controlled Trial.
Int J Clin Pediatr Dent
December 2024
Department of Pediatric and Preventive Dentistry, KVG Dental College and Hospital, Sullia, Karnataka, India.
Background: Early childhood caries (ECC) is a multifactorial disease with known etiologic factors and can be very devastating to the oral and general well-being of a child, including psychological impacts on a growing child. Young children constitute a vulnerable population because of their dependence and inability to communicate their needs. Oral health disparities continue to pose critical challenges, as ECC is the most common chronic disease of childhood.
View Article and Find Full Text PDFManagement of Catheter-Related Urethral Injuries in Male Children.
Cureus
December 2024
Paediatric Surgery, Bristol Royal Hospital for Children, Bristol, GBR.
Introduction: Management of urethral trauma lacks clarity in the paediatric population. There is no clear guidance for management and follow-up of these patients which can lead to missing the long-term sequelae of the primary injury. Catheter-associated urethral injuries are less likely to cause a complete transaction of the urethra.
View Article and Find Full Text PDFFrom past to present: tracing the trends of diabetes drug trials in mainland China.
Front Endocrinol (Lausanne)
January 2025
Department of Pharmacy, Nanjing Gaochun People's Hospital, Nanjing, Jiangsu, China.
Background: This study aimed to analyze the changing trend of diabetes drugs clinical trials in China during 2013-2023, and provided a reference for the research and development of diabetes drugs.
Methods: Diabetes drug clinical trial data were obtained from the registration and information disclosure platform of the National Medical Products Administration (NMPA) between January 1, 2013, and December 31, 2023. Trends of clinical trials on diabetes drugs were systematically analyzed in terms of characteristics, trial design, time trends, drug type, and indications.
Brief Report: Preventing Infusion-related Reactions With Intravenous Amivantamab: Results From SKIPPirr, a Phase 2 Study.
J Thorac Oncol
January 2025
Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.
Introduction: Amivantamab, an EGFR-MET bispecific antibody, is approved for multiple indications in EGFR-mutated advanced non-small cell lung cancer (NSCLC) as monotherapy or combined with other agents. Intravenous amivantamab is associated with a 67% infusion-related reactions (IRR) rate.
Methods: The phase 2 SKIPPirr study (NCT05663866) enrolled patients with EGFR-mutated (Ex19del/L858R) advanced NSCLC after progression on osimertinib and platinum-based chemotherapy who received intravenous amivantamab plus oral lazertinib (amivantamab-lazertinib), a third-generation tyrosine kinase inhibitor.
Anatomical limits of the parapharyngeal space using a transoral endoscopic approach - Radioanatomical study in cadaver.
Eur Arch Otorhinolaryngol
January 2025
Otorhinolaryngology Department, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
Purpose: The aim of this study is to obtain the anatomical limits of the parapharyngeal space by transoral surgical approach, in order to objectively determine the types of lesions according to location, where this type of approach is more indicated.
Methods: A prospective, experimental, radio-anatomical study was performed on 10 cryopreserved human heads(20 sides). A transoral approach of the parapharyngeal space was performed determining its anatomical limits by CT navigation.
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