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Influence of vascular embolism level and drug injection rate on thrombolytic therapy of bifurcated femoral vein: Numerical simulation and validation study.
Comput Methods Programs Biomed
December 2024
College of Mechanical and Electrical Engineering, Wenzhou University, Wenzhou, 325035, China.
Background And Objective: Deep vein thrombosis (DVT) of the lower limbs is a critical global vascular disease. Accurately assessing and predicting the efficacy of DVT treatment remains a significant challenge due to a lack of understanding of the mechanisms by which the level of patient-specific embolization and the rate of drug injection affect thrombolytic therapy.
Methods: In this study, we used the computed tomographic venography (CTV) clinical method to obtain patient-specific parameters, and the flow-solid interaction (FSI) method combined with biochemical response modeling of thrombolysis to analyze patient-specific hemodynamic and biomechanical characteristics and to quantitatively assess the effects of three vessel embolism levels (VEL) versus two drug injection rates (DIR) on bifurcated femoral venous thrombolytic therapy.
Development of a thrombin-antithrombin complex detection kit and study in venous thromboembolism complicated by cervical cancer.
BMC Biotechnol
December 2024
Department of Laboratory Medicine, Jiangnan University Hospital, Jiangsu Province, 1000 Hefeng Road, Wuxi City, 214122, No, China.
Objective: Our study successfully developed an assay kit for thrombin-antithrombin complex (TAT) and demonstrated the predictive value of plasma TAT concentration in the development of venous thromboembolism (VTE) in patients with cervical cancer.
Method: A retrospective analysis was conducted on 177 patients with cervical cancer who received treatment at the Affiliated Hospital of Jiangnan University in Wuxi City from July 1, 2023 to October 1, 2023. This study provides a comprehensive analysis of cervical cancer patients and their VTE risk factors.
Anticoagulation Usage and Thrombolytic Therapy in Subjects with Atrial Fibrillation Associated Ischaemic Stroke.
Int J Stroke
November 2024
Irish National Audit of Stroke, National Office of Clinical Audit. St Stephen's Green, Dublin 2. Ireland.
Background: Atrial Fibrillation (AF) causes up to 20% of ischaemic strokes and 30% in some populations such as those over 80 years. Previous research in our population showed that widespread adoption of Direct Oral Anticoagulant (DOAC) prophylaxis had not been associated with a reduction in AF associated stroke prevalence but there was a considerable rate of breakthrough stroke in patients receiving anticoagulation and anticoagulation rate may be affected by increasing use of DOACs.
Aims: We undertook a more detailed study using the Irish National Audit of Stroke (INAS) to determine the characteristics of anticoagulation practice in AF associated stroke, particularly breakthrough stroke, adherence to prescribing guidelines and effect on thrombolysis rate.
Purification, fibrinolytic activity and substrate binding of nattokinase from Bacillus subtilis: A rapid and sensitive detection for fibrinolytic activity of nattokinase.
Int J Biol Macromol
December 2024
Key Laboratory of Weak-Light Nonlinear Photonics, Ministry of Education, School of Physics, Nankai University, Tianjin 300071, PR China. Electronic address:
Article Synopsis
- Nattokinase (NK) is a protease with strong fibrinolytic activity, isolated from B. subtilis, and studied for its interaction with a fibrin-derived peptide substrate.
- High hydrolytic activity of NK towards the peptide was confirmed using FRET, with key kinetic parameters indicating effective substrate engagement.
- Binding studies revealed that the substrate interacts with NK primarily through hydrogen bonds and van der Waals forces, enabling a rapid and reproducible method for measuring NK's fibrinolytic activity in about 20 minutes.
Safety and efficacy of catheter-directed thrombectomy without thrombolysis in acute pulmonary embolism: A systematic review and meta-analysis.
Int J Cardiol
February 2025
Division of Pulmonary and Critical Care Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. Electronic address:
Article Synopsis
- * The research reviewed 18 studies involving 803 patients and found in-hospital mortality and major bleeding rates were low, at 1.8% and 2.1% respectively.
- * Results showed significant improvements in oxygen saturation and blood pressure after the procedure, suggesting that CDT offers beneficial hemodynamic outcomes and a favorable safety profile, supporting its increased use in clinical settings.
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