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http://dx.doi.org/10.1016/0002-8703(74)90015-5 | DOI Listing |
JAMA Netw Open
April 2024
Oncology Service, Geneva University Hospital, Geneva, Switzerland.
Importance: Randomized clinical trials (RCTs) with neoadjuvant immune checkpoint inhibitors (ICIs) plus chemotherapy (ICI-chemotherapy) for patients with early-stage non-small cell lung cancer (NSCLC) have reported consistent associations with event-free survival (EFS) and pathologic complete response (pCR) pending longer follow-up for overall survival data.
Objective: To assess the pooled benefit of ICI-chemotherapy in 2-year EFS and pCR among patients with NSCLC and examine the impact of clinical, pathologic, and treatment-related factors.
Data Sources: Full-text articles and abstracts in English were searched in EMBASE, PubMed, the Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews through November 1, 2023, and in oncology conference proceedings from January 1, 2008, to November 1, 2023.
Blue nevi are benign, melanocytic neoplasms that show a range of clinical and morphologic patterns and include common/dendritic, cellular, and atypical cellular subtypes. Like other nevi, they most commonly occur in skin but can occasionally involve lymph nodes where they may be misinterpreted as representing metastatic melanoma. Moreover, whether benign blue nevi can metastasize to lymph nodes and their natural history and prognostic significance has been the subject of great controversy.
View Article and Find Full Text PDFBalkan Med J
May 2022
Clinic of Oncology, University of Health Sciences Turkey, İzmir Bozyaka Training and Research Hospital, İzmir, Turkey
Background: Tumor budding is a histopathological finding that is accepted as an indicator of epithelial-mesenchymal transformation in many solid tumors. Axl is a Receptor Tyrosine Kinase (RTK) family member and contributes to epithelial-mesenchymal transformation. It has been reported that its overexpression in various solid cancer cells is associated with a poor prognosis.
View Article and Find Full Text PDFAEM Educ Train
February 2020
Department of Emergency Medicine University of California Irvine, Orange CA.
Background: The Accreditation Council for Graduate Medical Education (ACGME) requires that residency programs in emergency medicine plan at least 5 hours of didactic experiences per week. Instructional methods should include small-group techniques, problem-based learning, or computer-based instruction. Despite recommendations from the ACGME, many programs' conference didactics continue to include primarily lecture-based instruction.
View Article and Find Full Text PDFOral Surg Oral Med Oral Pathol Oral Radiol
January 2020
Department of Pathology, Rambam Medical Center, Bat Galim, Haifa, Israel; Technion School of Medicine, Bat Galim, Haifa, Israel.
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