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http://dx.doi.org/10.3181/00379727-145-37871 | DOI Listing |
Orphanet J Rare Dis
January 2025
Institute of Human Genetics, Leipzig University Medical Center, Leipzig, Germany.
Background: Cardiac rhabdomyoma (RHM) is considered one of the most frequent benign heart tumors in children. However, encounters with cardiac RHM in clinical practice remain rare. Clinical information is primarily available in the form of single case reports or smaller studies with a shortage of large-scale reviews encompassing a substantial number of cases.
View Article and Find Full Text PDFBr J Oral Maxillofac Surg
December 2024
Department of Oral and Maxillofacial Surgery, King's College Hospital, Denmark Hill, London SE5 9RS, United Kingdom.
The accelerated dental degree, pioneered by King's College London (KCL) to facilitate dual qualification training pathways for primary medical degree trainees, has graduated its fourteenth class. The authors present data to demonstrate and analyse the success of the course, which was accumulated through an online questionnaire, direct communication with the alumni, a freedom of information request from KCL, and review of the General Dental and Medical Council registers. To date 133 students have graduated with updated information collated for 132 (99.
View Article and Find Full Text PDFLife Sci
January 2025
Department of Neurosurgery, Philipps University of Marburg, Baldingerstraße, 35033 Marburg, Germany; Center for Mind, Brain and Behavior (CMBB), 35043 Marburg, Germany.
Background: X-ray, computed tomography (CT), and digital subtraction angiography (DSA) techniques are indispensable in managing critically ill neurosurgical patients. However, repeated diagnostic imaging leads to cumulative radiation exposure, raising concerns about long-term risks such as malignancies. This study evaluates the frequency, dosage, and implications of radiation exposure in a neurosurgical intensive care unit (NICU) patient cohort.
View Article and Find Full Text PDFLung Cancer
January 2025
Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, PR China. Electronic address:
Background: In the phase 3 ORIENT-11 study, sintilimab plus pemetrexed-platinum provided statistically significant longer overall survival and progression-free survival versus placebo plus pemetrexed-platinum as first-line treatment in patients with locally advanced or metastatic non-squamous non-small cell lung cancer (NSCLC). Here, we report the patient-reported outcomes (PRO) analysis findings in ORIENT-11.
Methods: PROs were measured using the European Organization for Research and Treatment of Cancer Quality of Life of Cancer Patients Questionnaire Core 30 items (EORTC QLQ-C30) and the Lung Cancer Symptom Scale (LCSS) questionnaire.
Econ Hum Biol
January 2025
Social Research Institute, University College London, UK.
Using two polygenic scores (PGS) for educational attainment in a biomedical study of all those born in a single week in Great Britain in 1958 we show that the genetic predisposition for educational attainment is associated with labour market participation and wages over the life-course for men and women. Those with a higher PGS spend more time in employment and full-time employment and, when in employment, earn higher hourly wages. The employment associations are four times larger for women than for men.
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